Issue 15, 2020

A fluorescent naphthalimide NADH mimic for continuous and reversible sensing of cellular redox state

Abstract

A fluorescent, naphthalimide-based, NADH mimic has been synthesised as a reversible, biocompatible, “on–off” probe for the detection of changes in intracellular redox environment (both oxidation and reduction). Interconversion was confirmed by means of electrochemistry and also 1H NMR, UV-vis and fluorescence spectroscopy. The reversibility was also successfully detected in A549 cells under simulated redox stress.

Graphical abstract: A fluorescent naphthalimide NADH mimic for continuous and reversible sensing of cellular redox state

Supplementary files

Article information

Article type
Communication
Submitted
16 Ker. 2019
Accepted
22 Gen. 2020
First published
22 Gen. 2020

Chem. Commun., 2020,56, 2240-2243

A fluorescent naphthalimide NADH mimic for continuous and reversible sensing of cellular redox state

H. Sharma, N. K. Tan, N. Trinh, J. H. Yeo, E. J. New and F. M. Pfeffer, Chem. Commun., 2020, 56, 2240 DOI: 10.1039/C9CC09748A

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