Issue 1, 2019

Degradable silver-based nanoplatform for synergistic cancer starving-like/metal ion therapy

Abstract

Developing a simple and degradable synergistic therapy nanosystem based on glucose oxidase (GOx) remains a challenge. Inspired by the chain reactions among silver nanoparticles, GOx and intratumoral glucose, a degradable GOx-conjugated silver nanocube (AgNC–GOx) for synergistic cancer starving-like/metal ion therapy is presented. The combination of glucose depletion, toxic H2O2 and Ag ions effectively inhibits tumor growth with minimal adverse effects.

Graphical abstract: Degradable silver-based nanoplatform for synergistic cancer starving-like/metal ion therapy

Supplementary files

Article information

Article type
Communication
Submitted
05 Eost 2018
Accepted
11 Here 2018
First published
23 Here 2018

Mater. Horiz., 2019,6, 169-175

Degradable silver-based nanoplatform for synergistic cancer starving-like/metal ion therapy

Y. Zhang, Y. Yang, S. Jiang, F. Li, J. Lin, T. Wang and P. Huang, Mater. Horiz., 2019, 6, 169 DOI: 10.1039/C8MH00908B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements