Issue 21, 2019

Manganese-catalyzed direct C–C coupling of α-C–H bonds of amides and esters with alcohols via hydrogen autotransfer

Abstract

Herein we report an efficient manganese-catalyzed C-alkylation of unactivated amides and tert-butyl acetate using alcohols as alkylating agents. This elegant approach exhibits a broad substrate scope providing the C–C coupled products of amides via a hydrogen auto-transfer strategy using aryl, heteroaryl, and aliphatic alcohols.

Graphical abstract: Manganese-catalyzed direct C–C coupling of α-C–H bonds of amides and esters with alcohols via hydrogen autotransfer

Supplementary files

Article information

Article type
Communication
Submitted
20 Ker. 2018
Accepted
12 Meur. 2019
First published
20 Meur. 2019

Dalton Trans., 2019,48, 7094-7099

Manganese-catalyzed direct C–C coupling of α-C–H bonds of amides and esters with alcohols via hydrogen autotransfer

J. Rana, V. Gupta and E. Balaraman, Dalton Trans., 2019, 48, 7094 DOI: 10.1039/C8DT05020A

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