Issue 7, 2016

The synthesis of di-carboxylate esters using continuous flow vortex fluidics

Abstract

A vortex fluidic device (VFD) is effective in mediating the synthesis of di-esters at room temperature. Processing under ambient conditions allows for a simple and efficient synthesis, whilst operating under continuous flow addresses scalability. The rotational speed of the sample tube and the flow rate were critical variables during reaction optimization, and this relates to the behaviour of the fluid flow at a molecular level. Whilst at specific rotational speeds the tube imparts a vibrational response into the fluid flow, the flow rate dictates residence time and the ability to maintain high levels of shear stress. The combination of mechanically induced vibrations, rapid micromixing, high levels of shear stress and water evaporation results in yields up to 90% for 3.25 minutes or less residence time. These results are key for devising greener and more efficient processes both mediated by the VFD and other continuous flow platforms.

Graphical abstract: The synthesis of di-carboxylate esters using continuous flow vortex fluidics

Supplementary files

Article information

Article type
Paper
Submitted
16 Here 2015
Accepted
30 Du 2015
First published
01 Ker. 2015

Green Chem., 2016,18, 2193-2200

Author version available

The synthesis of di-carboxylate esters using continuous flow vortex fluidics

J. Britton, S. B. Dalziel and C. L. Raston, Green Chem., 2016, 18, 2193 DOI: 10.1039/C5GC02494C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements