Issue 4, 2015

One-pot highly diastereoselective annulation to N-unprotected tetrasubstituted 2-pyrrolines

Abstract

A one-pot DABCO-catalysed Michael addition of glycine imine-derived esters to trans-2-aroyl-3-arylacrylonitriles followed by a deprotection/cyclization/tautomerization sequence afforded tetrasubstituted N-unprotected trans-2-pyrrolines in up to 96% yield.

Graphical abstract: One-pot highly diastereoselective annulation to N-unprotected tetrasubstituted 2-pyrrolines

Supplementary files

Article information

Article type
Communication
Submitted
10 Du 2014
Accepted
05 Gen. 2015
First published
06 Gen. 2015

Green Chem., 2015,17, 2137-2140

One-pot highly diastereoselective annulation to N-unprotected tetrasubstituted 2-pyrrolines

S. Meninno, A. Capobianco, A. Peluso and A. Lattanzi, Green Chem., 2015, 17, 2137 DOI: 10.1039/C4GC02191F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements