Issue 40, 2014

Multifunctional squalene-based prodrug nanoparticles for targeted cancer therapy

Abstract

Fluorescent and biotinylated squalene–gemcitabine prodrug nanoparticles exhibiting high drug payloads have been prepared and successfully used to target different cancer cell lines, resulting in increased cell uptake and improved anticancer efficiency, which represents the first targeted system derived from the squalenoylation approach.

Graphical abstract: Multifunctional squalene-based prodrug nanoparticles for targeted cancer therapy

Supplementary files

Article information

Article type
Communication
Submitted
28 Gwen. 2013
Accepted
17 Here 2013
First published
18 Here 2013

Chem. Commun., 2014,50, 5336-5338

Multifunctional squalene-based prodrug nanoparticles for targeted cancer therapy

D. T. Bui, J. Nicolas, A. Maksimenko, D. Desmaële and P. Couvreur, Chem. Commun., 2014, 50, 5336 DOI: 10.1039/C3CC47427E

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