Issue 39, 2013
From the journal:

Chemical Communications

Serum albumin enhances the membrane activity of ZnO nanoparticles†

Adam H. Churchman,a   Rachel Wallace,b   Steven J. Milne,b   Andy P. Brown,b   Rik Brydsonb  and  Paul A. Beales*a  

* Corresponding authors

a Centre for Molecular Nanoscience, School of Chemistry, University of Leeds, Leeds, UK
E-mail: p.a.beales@leeds.ac.uk

b Institute for Materials Research, SPEME, University of Leeds, Leeds, UK

Abstract

We investigate the effect of serum albumin on the interaction of ZnO nanoparticles with DOPC lipid membranes and show that the size-stabilizing effect of the protein corona enhances their interaction with lipid membranes, which manifests, in part, as an increased ordering in the lipid packing.

Graphical abstract: Serum albumin enhances the membrane activity of ZnO nanoparticles

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Article information

DOI
https://doi.org/10.1039/C3CC37871C
Article type
Communication
Submitted
01 Here 2012
Accepted
08 Gen. 2013
First published
08 Gen. 2013
This article is Open Access

Chem. Commun., 2013,49, 4172-4174

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Serum albumin enhances the membrane activity of ZnO nanoparticles

A. H. Churchman, R. Wallace, S. J. Milne, A. P. Brown, R. Brydson and P. A. Beales, Chem. Commun., 2013, 49, 4172 DOI: 10.1039/C3CC37871C

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