Issue 39, 2013

Rhodium-catalyzed cysteine modification with diazo reagents

Abstract

A simple rhodium(II) complex catalyzes cysteine modification with diazo reagents. The reaction is marked by clean cysteine selectivity and mild reaction conditions. The resulting linkage is significantly more stable in human plasma serum, when compared to common maleimide reagents.

Graphical abstract: Rhodium-catalyzed cysteine modification with diazo reagents

Supplementary files

Article information

Article type
Communication
Submitted
08 Here 2012
Accepted
12 Du 2012
First published
13 Du 2012

Chem. Commun., 2013,49, 4166-4168

Rhodium-catalyzed cysteine modification with diazo reagents

R. Kundu and Z. T. Ball, Chem. Commun., 2013, 49, 4166 DOI: 10.1039/C2CC37323H

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