Issue 21, 2024

Dendritic nanoparticles for immune modulation: a potential next-generation nanocarrier for cancer immunotherapy

Abstract

Immune activation, whether occurring from direct immune checkpoint blockade or indirectly as a result of chemotherapy, is an approach that has drastically impacted the way we treat cancer. Utilizing patients’ own immune systems for anti-tumor efficacy has been translated to robust immunotherapies; however, clinically significant successes have been achieved in only a subset of patient populations. Dendrimers and dendritic polymers have recently emerged as a potential nanocarrier platform that significantly improves the therapeutic efficacy of current and next-generation cancer immunotherapies. In this paper, we highlight the recent progress in developing dendritic polymer-based therapeutics with immune-modulating properties. Specifically, dendrimers, dendrimer hybrids, and dendronized copolymers have demonstrated promising results and are currently in pre-clinical development. Despite their early stage of development, these nanocarriers hold immense potential to make profound impact on cancer immunotherapy and combination therapy. This overview provides insights into the potential impact of dendrimers and dendron-based polymers, offering a preview of their potential utilities for various aspects of cancer treatment.

Graphical abstract: Dendritic nanoparticles for immune modulation: a potential next-generation nanocarrier for cancer immunotherapy

Article information

Article type
Minireview
Submitted
13 Cʼhwe. 2024
Accepted
23 Ebr. 2024
First published
23 Ebr. 2024

Nanoscale, 2024,16, 10208-10220

Dendritic nanoparticles for immune modulation: a potential next-generation nanocarrier for cancer immunotherapy

D. Kim, K. Javius-Jones, N. Mamidi and S. Hong, Nanoscale, 2024, 16, 10208 DOI: 10.1039/D4NR00635F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements