Issue 44, 2023

Enhancing the gastrointestinal stability of salmon calcitonin through peptide stapling

Abstract

Salmon calcitonin (sCT) is a polypeptide hormone available in the clinic. sCT is degraded in the gastrointestinal tract in minutes. In this work, a stapled analogue of salmon calcitonin, KaY-1(R24Q), was developed using the cooperative stapling between Lys and Tyr, with R24Q substitution. The analogue exhibited an improved stability in simulated gastric and intestinal fluid and retained the ability to activate the calcitonin receptor. This work will serve as a starting point for the development of an oral sCT drug.

Graphical abstract: Enhancing the gastrointestinal stability of salmon calcitonin through peptide stapling

Supplementary files

Article information

Article type
Communication
Submitted
08 Meur. 2023
Accepted
18 Ebr. 2023
First published
26 Ebr. 2023

Chem. Commun., 2023,59, 6682-6685

Enhancing the gastrointestinal stability of salmon calcitonin through peptide stapling

H. Ghareeb and N. Metanis, Chem. Commun., 2023, 59, 6682 DOI: 10.1039/D3CC01140B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements