Issue 9, 2022

Diversity-oriented routes to thiopeptide antibiotics: total synthesis and biological evaluation of micrococcin P2

Abstract

We report the first total synthesis of micrococcin P2 (MP2, 1) by a diversity-oriented route that incorporates a number of refinements relative to earlier syntheses. Biological data regarding the activity of 1 against a range of human pathogens are also provided. Furthermore, we disclose a chemical property of MP2 that greatly facilitates medicinal chemistry work in the micrococcin area and describe a method to obtain MP2 by fermentation in B. subtilis.

Graphical abstract: Diversity-oriented routes to thiopeptide antibiotics: total synthesis and biological evaluation of micrococcin P2

Supplementary files

Article information

Article type
Paper
Submitted
02 Du 2021
Accepted
24 Du 2021
First published
02 Ker. 2021

Org. Biomol. Chem., 2022,20, 1893-1899

Diversity-oriented routes to thiopeptide antibiotics: total synthesis and biological evaluation of micrococcin P2

H. Hwang, Y. Son, D. Kim, J. Lee, Y. Shin, Y. Kwon and M. A. Ciufolini, Org. Biomol. Chem., 2022, 20, 1893 DOI: 10.1039/D1OB02145A

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