Issue 24, 2022

Synthesis and characterization of a biocompatible 13C1 isotopologue of trityl radical OX071 for in vivo EPR viscometry

Abstract

We describe the synthesis, characterization, and application of an isotopologue of the trityl radical OX071, labeled with 13C at the central carbon (13C1). This spin probe features large anisotropy of the hyperfine coupling with the 13C1 (I = 1/2), leading to an EPR spectrum highly sensitive to molecular tumbling. The high biocompatibility and lack of interaction with blood albumin allow for systemic delivery and in vivo measurement of tissue microviscosity by EPR.

Graphical abstract: Synthesis and characterization of a biocompatible 13C1 isotopologue of trityl radical OX071 for in vivo EPR viscometry

Supplementary files

Article information

Article type
Paper
Submitted
16 Gwen. 2022
Accepted
07 Du 2022
First published
09 Du 2022

Analyst, 2022,147, 5643-5648

Synthesis and characterization of a biocompatible 13C1 isotopologue of trityl radical OX071 for in vivo EPR viscometry

M. Poncelet, T. Ngendahimana, T. D. Gluth, E. H. Hoblitzell, T. D. Eubank, G. R. Eaton, S. S. Eaton and B. Driesschaert, Analyst, 2022, 147, 5643 DOI: 10.1039/D2AN01527G

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