Issue 34, 2017

Aqueous RAFT at pH zero: enabling controlled polymerization of unprotected acyl hydrazide methacrylamides

Abstract

We report aqueous RAFT polymerization at pH = 0 mediated by a novel imidazolium-containing chain transfer agent. In 1 M HCl, unprecedented controlled polymerization and chain-extension of unprotected acyl hydrazide methacrylamides is achieved enabling the synthesis of well-defined acyl hydrazide functionalized polymer scaffolds of interest for dynamic covalent and bioconjugation strategies.

Graphical abstract: Aqueous RAFT at pH zero: enabling controlled polymerization of unprotected acyl hydrazide methacrylamides

Supplementary files

Article information

Article type
Communication
Submitted
06 Gwen. 2016
Accepted
15 Here 2016
First published
17 Here 2016

Polym. Chem., 2017,8, 4978-4982

Aqueous RAFT at pH zero: enabling controlled polymerization of unprotected acyl hydrazide methacrylamides

E. A. Hoff, B. A. Abel, C. A. Tretbar, C. L. McCormick and D. L. Patton, Polym. Chem., 2017, 8, 4978 DOI: 10.1039/C6PY01563H

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