Issue 20, 2016

Oxygen delivering biomaterials for tissue engineering

Abstract

Tissue engineering (TE) has provided promising strategies for regenerating tissue defects, but few TE approaches have been translated for clinical applications. One major barrier in TE is providing adequate oxygen supply to implanted tissue scaffolds, since oxygen diffusion from surrounding vasculature in vivo is limited to the periphery of the scaffolds. Moreover, oxygen is also an important signaling molecule for controlling stem cell differentiation within TE scaffolds. Various technologies have been developed to increase oxygen delivery in vivo and enhance the effectiveness of TE strategies. Such technologies include hyperbaric oxygen therapy, perfluorocarbon- and hemoglobin-based oxygen carriers, and oxygen-generating, peroxide-based materials. Here, we provide an overview of the underlying mechanisms and how these technologies have been utilized for in vivo TE applications. Emerging technologies and future prospects for oxygen delivery in TE are also discussed to evaluate the progress of this field towards clinical translation.

Graphical abstract: Oxygen delivering biomaterials for tissue engineering

Article information

Article type
Review Article
Submitted
14 Ker. 2015
Accepted
19 Cʼhwe. 2016
First published
22 Cʼhwe. 2016

J. Mater. Chem. B, 2016,4, 3422-3432

Oxygen delivering biomaterials for tissue engineering

A. L. Farris, A. N. Rindone and W. L. Grayson, J. Mater. Chem. B, 2016, 4, 3422 DOI: 10.1039/C5TB02635K

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