Themed collection Celebrating George Whitesides’ 85th birthday

An electrochemical sensing platform demonstrates the difference in NaCl uptake between salt-resistant and tolerant varieties of tomato and wild tomato seedlings.

Dendritic cell-targeted mRNA–PNP vaccines.

Incorporating mixed flexible-rigid backbones into molecular junctions can dynamically block tunneling currents and enhance rectification.

Surface-enhanced Raman scattering was used to resolve the chemical species, including chloride ions, on the surface of Ag nanocrystals in their original reaction solution, avoiding changes to the surface while eliminating possible artifacts.

3D structures of cells suspended in hydrogels are maintained under constant perfusion in a self-contained unit. The continuous flow delivery system (CFDS) expands upon previous work with paper and supported gel slab scaffolds.

A fluorescence-based pH-shift assay allows determination of the activity of a wide range of enzymes, demonstrated by the high-throughput screening of directed evolution libraries of transketolase on 3-hydroxyaldehydes.

Integration of 3D Printed Mg²⁺-ISE into a 3D printed microfluidic device for next-generation point-of-care diagnostic devices.

The paper introduces a photobleaching strategy for producing multiple bead populations on flow cytometry to accelerate and facilitate the discovery of antibody-binding pairs using a pooled antibody cross-testing assay.

An electrochemical microcentrifuge tube cap (ElectrochemCap) for integrated (bio)electroanalysis is demonstrated with a LAMP amplification reaction and its subsequent electrochemical detection. Adaptations for different containers are also presented.

Chemical language models can be fine-tuned to predict properties, like water solubility, given molecular inputs. This work investigates how these predictions may be explained.

This study describes a calibration-free device and method based on the resistive pulse sensing (RPS) principle for characterization of size distribution of extracellular vesicles (EVs).

A paper-based platform quantifies essential soil macronutrients (nitrate, magnesium, calcium, ammonium) using colorimetry and a smartphone. This device enhances soil fertility assessment, supporting precision agriculture and boosting food production.

We investigate the emergence of Turing patterns in a system growing as a rotating spiral in two dimensions, utilizing the photosensitivity of the chlorine dioxide–iodine–malonic acid (CDIMA) reaction to control the growth process.

Halogenated non-innocent vanadium(V) Schiff base mono-substituted catecholates have a low stability and anti-proliferative properties similar to vanadate. A linear correlation between complex redox potential and the catechol pK_a was observed.

Sputum of cystic fibrosis patients shows increased viscoelastic properties due to disulfide crosslinking. Treatment with the mucolytic polymer dPGS-SH reduces disulfide crosslinks, leading to decreased viscoelasticity in sputum samples.

3D cardiac muscle rings are proposed as autonomously driving actuators. We develop the biohybrid self-beating actuator powered by the cardiac muscle rings and confirm its periodic antagonistic beating motion with culture.

By locating the point of photo-scission close to the surface, the stability of the surface layer can be significantly reduced to permit substitution reactions after irradiation.

The surface oxidation of molybdenum carbide nanoparticles was controlled by the electrochemical method. The impact of surface oxidation on catalytic properties was studied by both spectroscopic and computational methods.

Stepwise temperature modulation was realized by the photothermal conversion process, which enabled the growth of complex architectures of CaCO₃ that are composed of multiple polymorphic phases.

Deformable, elastic materials that buckle in response to external stimuli can display “snap-through”, which involves a transition between different, stable buckled states.

VT-MAP, a novel in vitro platform, offers better physiological reflection through the vascularized organoid. This advancement supports drug assessment with deeper insights into cancer biology through correlation between morphology and drug effects.

Through a strategic polymer engineering design, this paper shows that self-immolative poly(phthalaldehyde) (PPA) can be employed as a responsive debonding-on-demand adhesive for the detection of fluorides and acids in liquid and solid states.