Synthon modularity is valuable for crystal structure prediction (CSP), allowing for the rationalization of polymorphs and co-crystals.
This study enables rapid synthesis of pomalidomide-conjugates for PROTACs by optimizing temperature and reagent addition, reducing reaction time to minutes with fewer byproducts, and improving efficiency and sustainability in drug development.
The fluorescent properties of pomalidomide derivatives have been utilised to develop a high-throughput imaging method suitable for rapid screening of protein degrader candidates.
Discovery timeline of HDAC8-degrading PROTACs.
This review summarizes the past and present advances in developing degraders of epigenetic targets which play critical roles in many crucial biological pathways and therefore, targeted for the discovery of therapeutics.