A stereodivergent synthesis of 2,5-disubstituted pyrrolidines from readily available amino alkynes was made possible under Au catalysis.
Iminium or azonium ions formed via classical condensation of amines with carbonyls or nitrosoarenes mediate C–H functionalizations of aliphatic amines under metal and oxidant free conditions.
‘Clip-Cycle’ approaches to enantiomerically enriched pyrrolidines, pyrrolizidines and indolizidines are derivatives, via sequential cross metathesis and aza-Michael reactions.
We report the synthesis of spirooxindole–pyrrolidines tethered with indole and pyridine heterocycles using 1,3-dipolar cycloaddition, and their anticancer activities and molecular docking studies.
A facile route to access N-fused pyrrolidines bearing a quaternary carbon from N-sulfonyl ketimines and commercially available trimethylenemethanes has been developed.