A stereodivergent synthesis of 2,5-disubstituted pyrrolidines from readily available amino alkynes was made possible under Au catalysis.
Iminium or azonium ions formed via classical condensation of amines with carbonyls or nitrosoarenes mediate C–H functionalizations of aliphatic amines under metal and oxidant free conditions.
‘Clip-Cycle’ approaches to enantiomerically enriched pyrrolidines, pyrrolizidines and indolizidines are derivatives, via sequential cross metathesis and aza-Michael reactions.
In this paper, we present the first combination of commercially available imine reductases (IREDs) with the photocatalytic hydroimination of alkene-tethered iminyl radicals.
Using a quinone monoacetal as the oxidant and DABCO as the base, we report the one-step synthesis of α-aryl-substituted pyrrolidines from pyrrolidine. The reaction of pyrrolidine and quinone monoacetal in 2,2,2-trifluoroethanol afforded octahydro-dipyrroloquinoline in high yield.