This minireview highlights recent advances in radical cyclization/addition of ynones. The content is organized according to product structure, providing a clearer overview and emphasizing the application value of ynones in radical chemistry.
During the past decade, photo- and electrochemical reactions proceeding via single-electron-transfer (SET) triggered radical pathways have emerged as an indispensable strategy for the efficient formation of chemical bonds.
Development of novel and efficient synthetic methods to achieve valuable N-heterocycles from aryldiazonium salts has been an important research area in organic chemistry for several decades.
We report a silver-catalyzed, diastereoselective cascade radical cyclization of quinolone olefins with diarylphosphine oxides, giving direct access to phosphorylated dihydrophenanthridinones bearing CF3-carbinol groups.
Cascade radical cyclization on 3-propargyl-2-alkenyl indole gives stereoselective access to cyclohepta[b]indole over carbazole.