A mechanochemically induced, nickel-catalyzed one-pot multicomponent protocol for a direct arylative detrifluoromethylation of ArCF3 is described. This reaction represents the first example of C–C coupling with CF3 as a leaving group.
An environmentally benign electrochemical decyanative C(sp3)–H oxygenation of N-cyanomethylamines for the synthesis of structurally diverse formamides is described.
A general and practical protocol is presented for visible-light-driven deoxygenative coupling of alcohols with aromatic nitriles in the absence of external photocatalysts.
A photoredox-catalyzed decarboxylative aminoalkylation of 4-cyanopyridines with N-arylglycines is achieved to provide 4-(aminomethyl)pyridine derivatives through a radical–radical cross-coupling process.
Photocatalytic α-C(sp3)–H pyridination of N-arylglycine derivatives and N-arylamines with cyanopyridines was developed through radical–radical cross-coupling under redox-neutral conditions.