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Discovery, biosynthesis, and bioactivities of peptidic natural products from marine sponges and sponge-associated bacteria

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Marine natural products

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New Chlorinated Meroterpenoids with Antifungal Activity from the Deep-Sea-Derived Fungus Acremonium sclerotigenum

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Marine Drugs, 2026, 24, 24
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Marine Natural Product Chagosendine C Induces Cuproptosis in Colorectal Cancer Cells by Targeting FDX1

Xiaoyu Tao, Hongru Wang, Qun Wang, Chengji Wang, Chang-Wei Shao, Yang Jin, Dianping Yu, Hongmei Hu, Qing Zhang, Mengting Xu, Xiangxin Geng, Hanchi Xu, Linyang Li, Ruling Shen, Yue-Wei Guo, Xu-Wen Li, Sanhong Liu and Weidong Zhang

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Polyketides with Cardioprotective Bioactivities from Sponge-Associated Fungus Aspergillus giganteus MA46-5

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Isolation of Four New Secondary Metabolites from the Cold Seep Chemosynthetic Ecosystem-Derived Fungus Arachnomyces bostrychodes

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Acremofurans A−M, antifungal benzofuran meroterpenoids from Acremonium sclerotigenum

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Phytochemistry, 2026, 248, 114909
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Biological and chemical investigation of metabolites from the marine sponge Geodia cydonium (Linnaeus, 1767) methanolic extract against melanoma cancer cell lines

Serena Federico, Roberta Esposito, Maria De Rosa, Valerio Zupo, Maria Costantini, Alessio Cimmino and Marco Masi

Natural Product Research, 2026, 1
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Targeted Isolation of ω-3 Polyunsaturated Fatty Acids from the Marine Dinoflagellate Prorocentrum lima Using DeepSAT and LC-MS/MS and Their High Activity in Promoting Microglial Functions

Chang-Rong Lai, Meng-Xing Jiang, Dan-Mei Tian, Wei Lu, Bin Wu, Jin-Shan Tang, Yi Zou, Song-Hui Lv and Xin-Sheng Yao

Marine Drugs, 2025, 23, 286
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Two new polyketide derivatives isolated from the mangrove-derived fungus Aspergillus sp. GXNU 2Y10

Fan He, Wenjun Li, Youquan Wei, Jiao Wu, Congli Lei, Zhenlan Li, Zheng Xiong and Xishan Huang

Natural Product Research, 2026, 1
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Marine metabolomics for bioactive material discovery: current trends, challenges, and future perspectives

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Anti-Inflammatory Secondary Metabolites from Penicillium sp. NX-S-6

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Marine Drugs, 2025, 23, 280
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Isolation, Structures, and Mechanisms of Anti-Tumor Peptides from Marine Organisms: A Review

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PPL, 2026, 33, 422
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New sterol and dihydroisocoumarin from the deep-sea derived fungus Cladosporium halotolerans HDN17-72

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Tetrahedron Letters, 2025, 160, 155555
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Breaking the antimicrobial resistance dilemma: marine natural products, a treasure trove for the development of new anti-Staphylococcus aureus drugs

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Mar Life Sci Technol, 2026
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Antioomycete activity and mechanism of neoechinulin A from the marine fungus Aspergillus amstelodami 012393 against Phytophthora capsici: neoechinulin A against Phytophthora capsici

Jin Cai, Fengman Yin, Guojun Zhou, Meng Yang, Mohan Zhang, Yonghao Chen, Sirong Li, Youping Luo, Mary Krinzy Charm Bañadera, Guolei Huang and Caijuan Zheng

Pest Management Science, 2025, 81, 8448
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New Phthalide Derivatives With Cardioprotective Effects From the Marine Fungus Diaporthe phaseolorum HZ‐2

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Chemistry & Biodiversity, 2026, 23
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Recent Advances of Secondary Metabolites From Marine‐Derived Aspergillus versicolor: Chemical Diversity and Bioactivities (2015–2024)

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Chemistry & Biodiversity, 2025, 22
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Development of venus-fused Cypridina luciferase (VCL) and specific nanobody-tethering assay to model kleptoprotein uptake

Risa Aoki, Akiko Nakanishi, Hotaka Atarashi, Kanchi Nanjo, Masahiko Hibi and Manabu Bessho-Uehara

Photochem Photobiol Sci, 2026
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OSMAC guided bioprospecting of Atlantic sponges reveals novel bacterial species and evidence for the antimicrobial thiazole alkaloid agrochelin II

Sam E. Williams, Henry L. Stennett, Andrew J. Devine, Zhongshu Song, Catherine R. Back, Luoyi Wang, Judith Mantell, Chris Neal, Mark A. Jepson, Angela E. Essex-Lopresti, Jonathan D. Sellars, James E. M. Stach, Christine L. Willis, Paul Curnow, Paul R. Race and Knut Rudi

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Asymmetric Total Synthesis of Streptoglycerides A and B

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Synlett, 2026, 37, 859
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PI3K-inhibitory new anthraquinone-xanthone heterodimers from a deep-sea Epichloe sp. SCSIO 41042

Ying-Ying Song, Xiao-Yan Pang, De-Hua Yang, Cheng-Hai Gao, Jun-Feng Wang and Yong-Hong Liu

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The potential of epoxide-containing marine natural products: sources, structures and bioactivities

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Antifungal secondary metabolites from a mangrove-derived fungus Daldinia eschscholtzii TGM23

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Journal of Asian Natural Products Research, 2026, 1
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Absolute Configuration of Symbiodinolactone A

Shin-ichiro Kurimoto, Kohei Nishie and Takaaki Kubota

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New Curvularin and Norlignanolide Derivatives From Cocultures of Marine Mangrove Endophytic Fungus Penicillium brocae MA‐231 and Phytopathogen Curvularia spicifera QA‐26

Ao‐Yuan Zhang, Xiao‐Shan Shi, Bin‐Gui Wang and Ling‐Hong Meng

Chemistry & Biodiversity, 2025, 22
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Vosamidines A–C, Polycyclic 2-Aminoimidazole Alkaloids from a Marine Calcareous Sponge Vosmaeropsis wilsoni

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Org. Lett., 2026, 28, 5329
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Antioomycete Activity and Mechanism of Territrem B, against Phytophthora capsici in Prevention of Phytophthora Blight

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Structural Diversity and Bioactivities of Marine Fungal Terpenoids (2020–2024)

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Marine Drugs, 2025, 23, 300
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Chemistry and pharmacology of naamine and naamidine-type marine alkaloids: an update

Christian Bailly

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Isomalabaricane Chemical Composition of Vietnamese Marine Sponges Inspected by Metabolomic and Chemical Approaches

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Marine Natural Products as Anticancer Agents 3.0

Celso Alves and Marc Diederich

Marine Drugs, 2025, 23, 243
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Discovery of Marine Highly Congested Polycyclic Isodhilarane-Type Meroterpenoids as Potential Leads for Treating Liver Fibrosis by Activating the HSF1/AMPK Metabolic Axis

Zhongping Jiang, Yue Chen, Shouyuan Wu, Junjie Wang, Feifei Liu, Jin Liu, Congjun Xu, Wanshan Li, Yong Rao and Ling Huang

J. Med. Chem., 2026, 69, 4346
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Synthesis of a Conformationally Fixed Bicyclomarin Derivative

Jennifer Greve, Alexander F. Kiefer and Uli Kazmaier

ChemMedChem, 2025, 20
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Unlocking the potential of marine natural product fragments for rational anticancer drug design: a computational approach

Marineil C. Gomez, Kavitha Rajendran and Lemmuel L. Tayo

Sci Rep, 2026, 16
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Diketopiperazines from marine-derived Exserohilum sp. M1-6

Rui Xu, Jianjian Wang, Changyu Liu, Xuefang Yang, Minjun Chen, Zihan Jin, Shengyan Zheng, Peihai Li, Cong Wang and Shugeng Cao

Natural Product Research, 2026, 1
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Antibacterial diphenyl ether derivatives from mangrove-derived fungus Aspergillus versicolor 21041517

Bin Wang, Jin Cai, Guojun Zhou, Mohan Zhang, Meng Yang, Yanxuan Li, Baoyi Zhang, Youping Luo, Nasihat, Xueming Zhou, Guolei Huang and Caijuan Zheng

Fitoterapia, 2026, 189, 107086
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Isolation and Cytotoxic Activities of Two New 2-Pyridone Alkaloids with Unique Structures from the Beibu Gulf Coral-Derived Acremonium sclerotigenum GXIMD 02501

Yuning Qin, Xinjian Qu, Miaoping Lin, Hong Zhang, Huangxue Qin, Chenghai Gao, Yonghong Liu, Xuefeng Zhou and Xiaowei Luo

J. Ocean Univ. China, 2026, 25, 1121
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Cratenin, a Rare Oxylipin Marking Kleptopredation in Aeolid Nudibranchs

Giulia Quaini, Federica Albiani, Marcello Ziaco, Laura Fioretto, Olimpia Follero, Carmela Gallo, Giuliana d’Ippolito, Emiliano Manzo, Genoveffa Nuzzo and Angelo Fontana

J. Nat. Prod., 2026
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Discovery of Eupenicillmarine A from the Marine Fungus Eupenicillium sp. HJ002 as a Natural Nematicide Candidate

Jin Cai, Xueming Zhou, Youzhi Yao, Mohan Zhang, Meng Yang, Yanxuan Li, Baoyi Zhang, Youping Luo, Guolei Huang and Caijuan Zheng

J. Agric. Food Chem., 2025, 73, 27562
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Smart Secondary Metabolites in Marine Environments: The Case of Elatol

Angélica R. Soares, Nathalia Nocchi, Ana R. Díaz-Marrero, Renato C. Pereira and José J. Fernández

Marine Drugs, 2026, 24, 61
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Genome Mining and Molecular Networking-Targeted Discovery of Siderophores with Plant Growth-Promoting Activities from the Marine-Derived Streptomonospora nanhaiensis 12A09T

Yan Bai, Weixian Gao, Wendian Zhao, Amr A. Arishi, Zhuo Shang, Jiangchun Hu and Huaqi Pan

Marine Drugs, 2025, 24, 7
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Azaspiromycin and pentalenolactone derivatives with insecticidal activities against Plutella xylostella from Streptomyces huasconensis NA10

Yan Bai, Meiyan Tan, Hailiang Sun, Xiaoke Wang, Xiaoyu Song, Jiangchun Hu and Huaqi Pan

Pest Management Science, 2026
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Sesquiterpenes from the Saudi Arabian Red Sea sponge Lamellodysidea herbacea

Mohamed A. Tammam, Leto-Aikaterini Tziveleka, Carlos M. Duarte, Efstathia Ioannou and Vassilios Roussis

Phytochemistry Letters, 2025, 67, 102969
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5Z-7-Oxozeanol Isolated from the Fungus Curvularia sp. MDCW-1060 Inhibits the Proliferation of MDA-MB-231 Cells via the PI3K-Akt and MAPK Pathways

Hong Zhang, Jianjian Wang, Chang Xu, Kai Liu, Jufang Xie, Zhoucheng He, Yonghong Liu, Cong Wang and Xinjian Qu

Marine Drugs, 2025, 23, 414
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Fucosterol from marine algae: a multifunctional marine phytosterol with health benefits-from dietary component to functional ingredient

Shasha Guo, Xiaochun Liu, Yanchun Gao, Fangxue Xu and Xiaozhi Xi

Food Chemistry: X, 2026, 36, 103998
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The Chemistry and Pharmacology of the Alkaloid Barettin and Its Analogues from the Marine Sponge Geodia barretti: Progress and Perspectives

Christian Bailly

Marine Drugs, 2026, 24, 110
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More than a Thickener: Xanthan Gum as a Vehicle for the Herbicidal Extract of Saussurea lappa and Its Rheological Characterization

Shafiu Mustapha, Bryan N. S. Pinto, Ângelo M. L. Denadai and Elson S. Alvarenga

Plants, 2026, 15, 337
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Cyanobacterial peptides and polyketides: biosynthetic basis, structural diversity and therapeutic relevance

Abhishek Chauhan, Anuj Ranjan, Neelam Mishra, Hardeep Singh Tuli, Ritu Chauhan, Damandeep Kaur, Laurent Dufossé and Naveen Chandra Joshi

Medicine in Drug Discovery, 2026, 100259
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Marine Bacteria as a Source of Antibiotics Against Staphylococcus aureus: Natural Compounds, Mechanisms of Action, and Discovery Strategies

Céphas Xuma, Alexandre Bourles, Julien Colot, Linda Guentas and Mariko Matsui

Marine Drugs, 2026, 24, 44
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Structurally specialised metabolites with antimicrobial and enzyme inhibitory activities from Hadal Trench-derived Nigrocephalum sp. SCSIO41049

Qinlin Cao, Xiaoyan Pang, Mengjing Cong, Ziqing Li, Junfeng Wang, Xuefeng Zhou, Bin Yang, Weijia Zhang and Yonghong Liu

Phytochemistry, 2026, 244, 114749
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Proteomic Studies for the Identification and Characterization of Marine Bioactive Molecules

Nedeljka Rosic

Marine Drugs, 2025, 23, 433
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The rise of marine fungi: Drug discovery's blue frontier

Eva Breyer and Federico Baltar

Clinical & Translational Med, 2026, 16
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Exploring the associations among halogenated compounds in Asparagopsis taxiformis: temporal shifts and bacterial impacts under intensive cultivation

S. Blanco-González, P.R. Brooks, D.A. Heyne, A.H. Campbell, S.F. Cummins and N.A. Paul

Algal Research, 2026, 94, 104513
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The sea walnut Mnemiopsis leidyi: from ecological nuisance to potential biological resource

Cristina Munari and Michele Mistri

Front. Mar. Sci., 2026, 13
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Total Synthesis and Biological Evaluation of Prealnumycin B

Kei Kitamura, Tatsuro Yoneyama, Masaaki Noji and Hiroto Kaku

Chem. Pharm. Bull., 2025, 73, 707
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New alkaloids from the marine-derived fungus Penicillium sp. SWMU-WZ04-5 and their cytotoxic activity

Sijing Liu, Jinghao Cui, Mengyu Zhang, Ting Chen, Fengjian Lan, Xiujuan Fu, Siwei Chen, Dan Zhang, Ying Zhang and Hui Lei

Phytochemistry Letters, 2026, 73, 104150
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Marine natural products with anti-MRSA activities: promising candidates for antibacterial drug discovery

Mei-Jun Chu, Qian-Qian Wu, Bao-Tao Liu, You-Zhi Li and Ming Zou

Bioorganic Chemistry, 2025, 167, 109242
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Chemical Constituents of Deep‐Sea‐Derived Fungus Penicillium citrinum W17 and Their Ferroptosis Inhibitory Activity

A‐Long Zhang, Zheng‐Biao Zou, Yan‐Qing Guo, Wen‐Si Su, Chun‐Lan Xie, Li‐Sheng Li, Cheng‐Hai Gao and Xian‐Wen Yang

Chemistry & Biodiversity, 2026, 23
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Antifungal activity and mechanism of an alkaloid derived from the marine fungus Aspergillus terreus BYS8 against Botrytis cinerea

Jin Cai, Feng‐Man Yin, Guo‐Jun Zhou, Long‐Tao Huang, Bao‐Yi Zhang, Yan‐Xuan Li, Xue‐Ming Zhou, You‐Ping Luo, Peng‐Fei Deng and Cai‐Juan Zheng

Pest Management Science, 2026, 82, 2489
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Computational investigation of African natural products as Helicobacter pylori shikimate kinase inhibitors

Hari Ram Sharma Paudel and Javed Iqbal

PLoS One, 2026, 21, e0346899
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Spatiotemporal Distribution Characteristics of Phytoplankton in Sizaopu River, Ningbo Qianwan New Area

Yue Zhi and Qing Liu

E3S Web Conf., 2026, 711, 01020
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