New progress in hydrogen-synergistic diagnostic and therapeutic nanoplatforms for tumor treatment

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Biomater. Sci., 2026, 14, 1180
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A porous material excited by near-infrared light for photo/chemodynamic and photothermal dual-mode combination therapy

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J. Mater. Chem. B, 2020, 8, 10559
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Hydrogen therapy: recent advances and emerging materials

Zheng Jiang, Mailudan Ainiwaer, Jun Liu, Binwu Ying, Fengming Luo and Xuping Sun

Biomater. Sci., 2024, 12, 4136
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Metal-based micro/nanomaterials for hydrogen therapy and their biomedical applications

Yu Wang, Haoyu Wang, Handan Zhang, Tao Liu and Xin Chen

Nanoscale, 2025, 17, 13594
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Recent advances in the development of metal–organic framework-basedgas-releasingnanoplatforms for synergistic cancer therapy

Danni Jin, Jianan Zhang, Youyou Huang, Xiru Qin, Jiayi Zhuang, Wujie Yin, Sijie Chen, Yang Wang, Ping Hua and Yong Yao

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AgBiS2-TPP nanocomposite for mitochondrial targeting photodynamic therapy, photothermal therapy and bio-imaging under 808 nm NIR laser irradiation

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Near-infrared-driven upconversion nanoparticles with photocatalysts through water-splitting towards cancer treatment

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Ultrasound-targeted microbubble destruction augmented synergistic therapy of rheumatoid arthritis via targeted liposomes

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SiO2@Cu7S4 nanotubes for photo/chemodynamic and photo-thermal dual-mode synergistic therapy under 808 nm laser irradiation

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Metal-free carbon dots toward bio-green hydrogen evolution via photocatalysis

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Recent advances in improving tumor-targeted delivery of imaging nanoprobes

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Application trends of hydrogen-generating nanomaterials for the treatment of ROS-related diseases

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Tumor microenvironment-activated NIR-II reagents for tumor imaging and therapy

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Bioactive inorganic nanomaterials for cancer theranostics

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Gas and gas-generating nanoplatforms in cancer therapy

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Hydrogen Medicine Materials

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Molecular Hydrogen Therapy: Mechanisms, Delivery Methods, Preventive, and Therapeutic Application

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MedComm, 2025, 6
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Status quo, challenges and future directions of hydrogen medicine

Shengqiang Chen, Lingting Zeng and Qianjun He

Fundamental Research, 2026, 6, 1242
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Laser-triggered combination therapy by iron sulfide-doxorubicin@functionalized nanozymes for breast cancer therapy

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J Nanobiotechnol, 2021, 19
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Redox regulation and its emerging roles in cancer treatment

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Hydrogen agronomy: research progress and prospects

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Zn-Fe primary battery-enabled controlled hydrogen release in stomach for improving insulin resistance in obesity-associated type 2 diabetes

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Bioactive Materials, 2024, 33, 242
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Palladium Hydride Nanopocket Cubes and Their H2‐Therapy Function in Amplifying Inhibition of Foam Cells to Attenuate Atherosclerosis

Min Xu, Yue Zhou, Chuchu Ren, Xiaoyang Liang and Nan Li

Adv Funct Materials, 2021, 31
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Hydrogen‐Powered Microswimmers for Precise and Active Hydrogen Therapy Towards Acute Ischemic Stroke

Shuanghu Wang, Kun Liu, Quan Zhou, Cong Xu, Junbin Gao, Zhen Wang, Fei Wang, Bin Chen, Yicheng Ye, Juanfeng Ou, Jiamiao Jiang, Daniela A. Wilson, Shuwen Liu, Fei Peng and Yingfeng Tu

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Controlled release of hydrogen by implantation of magnesium induces P53-mediated tumor cells apoptosis

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Nanomaterial-mediated sustainable hydrogen supply induces lateral root formation via nitrate reductase-dependent nitric oxide

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Chemical Engineering Journal, 2021, 405, 126905
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The Landscape of Smart Biomaterial‐Based Hydrogen Therapy

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Advanced Science, 2024, 11
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Modulating the Electronic Structure of MnNi2S3 Nanoelectrodes to Activate Pyroptosis for Electrocatalytic Hydrogen‐Immunotherapy

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Microneedle Mediated Gas Delivery for Rapid Separation, Enhanced Drug Penetration, and Combined Therapy

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New Possibilities of the Prevention and Treatment of Cardiovascular Pathologies. The Potential of Molecular Hydrogen in the Reduction of Oxidative Stress and its Consequences

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MXene-Engineered MgB2 Nanoprodrugs with Acid-Responsive Hydrogen Evolution for Cooperative Photothermal Cancer Ablation

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ACS Appl. Mater. Interfaces, 2026, 18, 12506
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Engineered Nanostructured Photocatalysts for Cancer Therapy

Javier Bonet-Aleta, Jose I. Garcia-Peiro and Jose L. Hueso

Catalysts, 2022, 12, 167
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Magnesium-based micromotors for enhanced active and synergistic hydrogen chemotherapy

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Applied Materials Today, 2020, 20, 100694
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Delivery of Molecular Hydrogen for Precision Immunomodulation: Mechanisms, Detection Methods, and Applications

Gangfeng Li, Hannan Cui, Ruixiao Fan, Guming Liu, Zishuo Hou, Yibo Zhang, Xuanming Che, Tengjiao Wang, Hongbo Wei and Peng Li

Advanced Science, 2025, 12
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Mesocrystalline ZnS nanoparticles-augmented sonocatalytic full water splitting into H2/O2 for immunoactivating deep tumor

Chao Xia, Anbang Wu, Zhaokui Jin, Lingting Zeng, Lingdong Jiang, Qingqing Xu, Mingjian Fan and Qianjun He

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О. О. Покотило, О. С. Покотило and М. М. Корда

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Heterojunction semiconductor nanocatalysts as cancer theranostics

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A hydrogen generator composed of poly (lactic-co-glycolic acid) nanofibre membrane loaded iron nanoparticles for infectious diabetic wound repair

Xiangqi Zhang, Wei Yu, Yihui Zhang, Wenkai Zhang, Jiayu Wang, Muge Gu, Sulin Cheng, Guogang Ren, Bo Zhao and Wei-En Yuan

Journal of Colloid and Interface Science, 2024, 672, 266
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Hydrogen Promotes the Effectiveness of Bone Mesenchymal Stem Cell Transplantation in Rats with Spinal Cord Injury

Shengchang Luo, Jianxin Wu, Yuanyuan Qiu, Bing Xiao, Yanhai Xi, Chengwei Yang, Zhicai Shi, Weiheng Wang and Oswaldo Keith Okamoto

Stem Cells International, 2023, 2023, 1
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Nanomaterials‐Induced Redox Imbalance: Challenged and Opportunities for Nanomaterials in Cancer Therapy

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Molecular hydrogen is a promising therapeutic agent for pulmonary disease

Zhiling Fu and Jin Zhang

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Role of Magnesium in Tumor Microenvironment and Underlying Molecular Mechanisms

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Gas immnuo-nanomedicines fight cancers

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Photocatalysis-mediated drug-free sustainable cancer therapy using nanocatalyst

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Novel gas‐based nanomedicines for cancer therapy

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pH-Responsive Delivery of H2 through Ammonia Borane-Loaded Hollow Polydopamine for Intervertebral Disc Degeneration Therapy

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Microfactories for Intracellular Locally Generated Hydrogen Therapy: Advanced Materials, Challenges, and Opportunities

Yuli Ma, Fang Wu and Yun Hang Hu

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Acid‐Degradable Hydrogen‐Generating Metal‐Organic Framework for Overcoming Cancer Resistance/Metastasis and Off‐Target Side Effects

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Mitochondrial ‘Birth-Death’ coordinator: An intelligent hydrogen nanogenerator to enhance intervertebral disc regeneration

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pH-Responsive Injectable Multifunctional Pluronic F127/Gelatin-Based Hydrogels with Hydrogen Production for Treating Diabetic Wounds

Tian Zhang, Xin Cheng, Jingya Xiu, Min Liu, Siyi Liu, Bowen Zhang, Qi Miao, Dongyun Cun, Chunrong Yang, Kexin Li, Jiulong Zhang and Xiuli Zhao

ACS Appl. Mater. Interfaces, 2023, 15, 55392
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Critical learning from industrial catalysis for nanocatalytic medicine

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Advances in hydrogen delivery strategies for therapeutic applications

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Ultrasound‐Assisted H2 Transmitter Enables Hydrogen‐Gene Therapy to Prevent Anesthesia/Surgery‐Induced Cognitive Impairment

Ruonan Zhan, Yan Fang, Chuyun Lou, Nan Chen, Xuan Mo, Bo Jiao, Mengke Liu, Yangxi Zhao, Weichen Xu, Huixiong Xu, Haohao Yin and Yi Zhang

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Strategies for engineering advanced nanomedicines for gas therapy of cancer

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A ‘targeting-and-control’ nanoplatform framework for precision gas therapy of cancer

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Micro/Nanomaterials‐Augmented Hydrogen Therapy

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Nanocomposite hydrogel to integratively inhibit bacteria and inflammation for infected wound repair

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Photodriven nanoreactor with a hydrogen-insulin double act repairs diabetic wounds through Nrf2 pathway activation

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Chemical Engineering Journal, 2021, 425, 131800
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Simply Designed and Universal DNA Nanohydrogel for Stimuli-Responsive NIR-II Fluorescence Imaging of Early-Stage Tumor

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Hierarchical and flexible electrode with precise H2-production for in vivo liver cancer therapy

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Chinese Chemical Letters, 2025, 36, 110866
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Second near-infrared nanomaterials for cancer photothermal immunotherapy

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Therapeutic gas delivery strategies

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Smart Hydrogen‐Producing Nanoparticles with the Potential for Arthritic Microenvironment Regulation

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Magnetic hyperthermia-induced hydrogen therapy for cancer treatment using PEG-coated Mg–Ni Degradable microrobots

Sourav Dutta, Tanushree Patra, Kyungmoo Yea and Hongsoo Choi

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NIR-Driven Water Splitting H2 Production Nanoplatform for H2-Mediated Cascade-Amplifying Synergetic Cancer Therapy

Qi Wang, Yishun Ji, Jinsheng Shi and Lili Wang

ACS Appl. Mater. Interfaces, 2020, 12, 23677
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Thiol-Responsive Polypeptide Sulfur Dioxide Prodrug Nanoparticles for Effective Tumor Inhibition

Yu Zhang, Xinming Liu, Pan He, Bingtong Tang, Chunsheng Xiao and Xuesi Chen

Biomacromolecules, 2023, 24, 4316
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Advances in hydrogen therapy and hydrogen administration biomaterials for respiratory diseases

Yi Gong, Tairan Quan, Qingqing Guan, Han Li, Jianfeng Tong and Jia Pei

Sci. China Mater., 2026
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New Approaches for Hydrogen Therapy of Various Diseases

Lei Zhang, Han Yu, Qiufen Tu, Qianjun He and Nan Huang

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Advanced Strategies and Innovative Theragenerative Nano/Micro Biomaterials for Bone Cancer Therapy and Bone Tissue Regeneration with a Focus on Osteosarcoma Management

Jihene Arfaoui, Abdelhamid Ghorbel, Sanjay Mathur and Hajar Maleki

ACS Biomater. Sci. Eng., 2026, 12, 1334
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Palladium Nanocrystals‐Engineered Metal–Organic Frameworks for Enhanced Tumor Inhibition by Synergistic Hydrogen/Photodynamic Therapy

Jiajie Chen, Shiyang Lin, Doudou Zhao, Lei Guan, Yaping Hu, Yitong Wang, Kaili Lin and Yufang Zhu

Adv Funct Materials, 2021, 31
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“Green” gas-generation strategy to combine cancer phototherapy for remarkably enhanced efficacy

Jiahui Wu, Gege Zhang, Mi Zou, Qiong Huang, Yanling Zhang, Yajie Sui, Shuang Wu, Jianming Yang, Qiaojun Fang and Pingping Liang

Nano TransMed, 2025, 4, 100090
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Recent advances in the application of gasotransmitters in spinal cord injury

Xiang Gao, Bingrong Jin, Xiaozhong Zhou, Jinyu Bai, Hao Zhong, Kai Zhao, Zongrui Huang, Chao Wang, Jiang Zhu and Qin Qin

J Nanobiotechnol, 2024, 22
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Palladium hydride nanourchins with amplified photothermal therapeutic effects through controlled hydrogen release and antigen-assisted immune activation

Hao Chen, Binbin Ding, Jia Tan, Pan Zheng, Ziyong Cheng, Ping'an Ma and Jun Lin

Chemical Engineering Journal, 2022, 442, 136296
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Innovative hydrogen delivery platforms for enhanced biomedical applications

Arman Barzgar, Iman Barzgar, Javad Esmaeili and Saeedeh Zare Jalise

International Journal of Hydrogen Energy, 2025, 193, 152412
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Microbial hydrogen “manufactory” for enhanced gas therapy and self-activated immunotherapy via reduced immune escape

Hongyu Yan, Miao Fan, Huifang Liu, Tingshan Xiao, Dandan Han, Ruijun Che, Wei Zhang, Xiaohan Zhou, June Wang, Chi Zhang, Xinjian Yang, Jinchao Zhang and Zhenhua Li

J Nanobiotechnol, 2022, 20
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Molecular Hydrogen: From Molecular Effects to Stem Cells Management and Tissue Regeneration

Mikhail Yu. Artamonov, Andrew K. Martusevich, Felix A. Pyatakovich, Inessa A. Minenko, Sergei V. Dlin and Tyler W. LeBaron

Antioxidants, 2023, 12, 636
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