Sulfone promoted Rh(iii)-catalyzed C–H activation and base assisted 1,5-H shift strategy for the construction of seven-membered rings

Abstract

A facile synthesis of thiepine sulfones is described. It relies on a sequence of Rh(III)-catalyzed C–H cleavage, 1,5-H shift, and intramolecular allene insertion. As a result of extremely readily accessible starting materials and convenient operation, this protocol should be an appealing strategy in organic synthesis.