Issue 17, 2014

NIR luminescent nanomaterials for biomedical imaging

Abstract

Luminescent labels have been widely used for biological applications, primarily in bioimaging and assays. Recently much attention has been focused on the development of luminescent nanoprobes with excitation/emission maxima falling in the region of minimal tissue absorbance/autofluorescence between 650 and 1450 nm, an “imaging window”. Tissues have minimal absorbance in this wavelength range allowing for deep penetration of light. This enables whole animal imaging with high sensitivity in core organs in real time without the need for dissection. While several excellent reviews cover various aspects of imaging, there has not been a review that covers NIR imaging nanomaterials adequately. In the present review, we will focus on nanomaterials which can be excited or emitted in NIR I (650–900 nm) and NIR II (1000–1450 nm) regions, including lanthanide based nanoparticles, carbon based nanoparticles, quantum dots and noble metal nanomaterials. We systematically summarize the recent progress in their fabrication and application in biomedical imaging, and discuss the shortcomings, challenges and opportunities in it.

Graphical abstract: NIR luminescent nanomaterials for biomedical imaging

Article information

Article type
Feature Article
Submitted
16 অক্টো. 2013
Accepted
06 ডিসে. 2013
First published
06 ডিসে. 2013

J. Mater. Chem. B, 2014,2, 2422-2443

NIR luminescent nanomaterials for biomedical imaging

R. Wang and F. Zhang, J. Mater. Chem. B, 2014, 2, 2422 DOI: 10.1039/C3TB21447H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements