Issue 18, 2024

Advances in magnetoelectric composites for promoting bone regeneration: a review

Abstract

Repair of large bone defects is one of the clinical problems that have not yet been fully solved. The dynamic balance of bone tissue is regulated by many biological, chemical and physical environmental factors. Simulating the microenvironment of bone tissue in the physiological state through biomimetic materials is an important development direction of tissue engineering in recent years. With the deepening of research, it has been found that when bone tissue is damaged, its surrounding magnetoelectric microenvironment is subsequently destroyed, and providing a magnetoelectric microenvironment in the biomimetic state will be beneficial to promote bone repair. This review describes the piezoelectric effect of natural bone tissue with magnetoelectric stimulation for bone regeneration, provides a detailed account of the historical development of magnetoelectric composites and the current magnetoelectric composites that are most commonly utilized in the field of tissue engineering. Besides, the hypothesized mechanistic pathways through which magnetoelectric composite materials promote bone regeneration are critically examined, including the enhancement of osteogenesis, promotion of cell adhesion and angiogenesis, modulation of bone immunity, and promotion of nerve regeneration.

Graphical abstract: Advances in magnetoelectric composites for promoting bone regeneration: a review

Article information

Article type
Review Article
Submitted
05 নভে. 2023
Accepted
07 এপ্রিল 2024
First published
19 এপ্রিল 2024

J. Mater. Chem. B, 2024,12, 4361-4374

Advances in magnetoelectric composites for promoting bone regeneration: a review

C. Li, A. Zhu, L. Yang, X. Wang and Z. Guo, J. Mater. Chem. B, 2024, 12, 4361 DOI: 10.1039/D3TB02617E

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