Issue 11, 2021

Stereoselective synthetic strategies of stereogenic carbon centers featuring a difluoromethyl group

Abstract

Difluoromethyl groups possess specific steric and electronic properties due to their slightly acidic C–H bonds and the natural characteristics of fluorine atoms, which allow them to act as chemically inert hydrogen-bond donors and then as surrogates in a wide assortment of important molecular recognition processes. As a result, the construction of chiral carbon centres bearing difluoromethyl groups is not only valuable for the synthesis of various fluorine-containing compounds, but also useful for the modulation of the properties of organic compounds in drug design. The scope of this review is to summarize routine asymmetric synthetic methods which enable the effective and selective introduction of difluoromethyl groups into the desired compounds.

Graphical abstract: Stereoselective synthetic strategies of stereogenic carbon centers featuring a difluoromethyl group

Article information

Article type
Review Article
Submitted
14 জানু. 2021
Accepted
13 মার্চ 2021
First published
15 মার্চ 2021

Org. Chem. Front., 2021,8, 2799-2819

Stereoselective synthetic strategies of stereogenic carbon centers featuring a difluoromethyl group

F. Gao, B. Li, Y. Wang, Q. Chen, Y. Li, K. Wang and W. Yan, Org. Chem. Front., 2021, 8, 2799 DOI: 10.1039/D1QO00032B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements