Issue 1, 2021

In vivo vocal fold augmentation using an injectable polyethylene glycol hydrogel based on click chemistry

Abstract

It is important to focus on urgent needs in clinics and develop optimal materials. For successful augmentation of vocal folds, the ideal filler should be injectable through a syringe, and should stably maintain its volume for a long time without toxicity. To achieve these criteria, a click chemistry-based PEG (polyethylene glycol) hydrogel was developed and applied for vocal fold augmentation in vivo. The PEG hydrogel enables fast gelation in vivo after injection and provides long-term stability. Azide- and dibenzocyclooctyne (DBCO)-modified 4-arm PEG were cross-linked by chemical conjugation via click chemistry and yielded gelation within several minutes. After subcutaneous injection into mice and rats, the PEG hydrogel showed higher stability after 1 month compared to the traditionally used calcium hydroxyapatite–carboxymethyl cellulose (CaHA-CMC) filler. In rabbit models with vocal fold paralysis, the PEG hydrogel stably fixed the paralyzed vocal fold in 4 months and minimized the glottic gap. It was an improved therapeutic result compared to CaHA-CMC, demonstrating the potential of a click chemistry-based PEG hydrogel for vocal fold therapy.

Graphical abstract: In vivo vocal fold augmentation using an injectable polyethylene glycol hydrogel based on click chemistry

Supplementary files

Article information

Article type
Paper
Submitted
13 জুলাই 2020
Accepted
12 অক্টো. 2020
First published
15 অক্টো. 2020

Biomater. Sci., 2021,9, 108-115

In vivo vocal fold augmentation using an injectable polyethylene glycol hydrogel based on click chemistry

S. Kwon, H. Choi, C. Park, S. Choi, E. Kim, S. W. Kim, C. Kim and H. Koo, Biomater. Sci., 2021, 9, 108 DOI: 10.1039/D0BM01155J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements