Mithila D. Bandara, Keith J. Stine and Alexei V. Demchenko
Org. Biomol. Chem., 2020,18, 1747-1753
DOI:
10.1039/D0OB00172D,
Paper
The first chemical synthesis of lacto-N-neohexaose (LNnH) has been completed using a convergent synthetic strategy. The reaction conditions and donor–acceptor combinations have been carefully refined to minimize side reactions and achieve high yields in all glycosylation steps. Lacto-N-neotetraose, another common human milk oligosaccharide, was also synthesized en route to the target LNnH.
