Issue 1, 2018

Chemical analysis in saliva and the search for salivary biomarkers – a tutorial review

Abstract

Biomarkers refer to analytes that can be used in the diagnosis of diseases or disorders. In saliva, there are many components that are potential biomarkers, and increasing research has focussed on the development of saliva as a diagnostic fluid. This review summarizes the existing uses of salivary biomarkers and highlights the importance of the choice of saliva collection as well as the storage procedures. A case study on the effect of collection tools on the concentrations of one of the potential biomarkers, glutathione, is highlighted. Moreover, molecular diagnosis requires reliable measurement assays. This review presents electroanalytical methods for the detection of salivary biomarkers. It further reviews approaches that can be taken to improve the selectivity of electroanalytical assays without the use of biologically selective materials, notably without the use of enzymes or antibodies.

Graphical abstract: Chemical analysis in saliva and the search for salivary biomarkers – a tutorial review

Associated articles

Article information

Article type
Tutorial Review
Submitted
21 সেপ্টে. 2017
Accepted
01 নভে. 2017
First published
03 নভে. 2017

Analyst, 2018,143, 81-99

Chemical analysis in saliva and the search for salivary biomarkers – a tutorial review

K. Ngamchuea, K. Chaisiwamongkhol, C. Batchelor-McAuley and R. G. Compton, Analyst, 2018, 143, 81 DOI: 10.1039/C7AN01571B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements