Issue 9, 2015

Copper-mediated oxidative difluoromethylation of terminal alkynes with TMSCF2H

Abstract

A copper-mediated oxidative difluoromethylation of terminal alkynes using nucleophilic TMSCF2H in the presence of an oxidant 9,10-phenanthraquinone was developed. This reaction provided a direct and efficient method for preparation of difluoromethylated alkynes.

Graphical abstract: Copper-mediated oxidative difluoromethylation of terminal alkynes with TMSCF2H

Supplementary files

Article information

Article type
Research Article
Submitted
11 জুন 2015
Accepted
27 জুন 2015
First published
29 জুন 2015

Org. Chem. Front., 2015,2, 1022-1025

Copper-mediated oxidative difluoromethylation of terminal alkynes with TMSCF2H

S. Zhu, X. Xu and F. Qing, Org. Chem. Front., 2015, 2, 1022 DOI: 10.1039/C5QO00186B

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