Issue 58, 2014
From the journal:

Chemical Communications

Dual pH-triggered multistage drug delivery systems based on host–guest interaction-associated polymeric nanogels†

Minghui Zan,ab   Junjie Li,a   Shizhong Luo*b  and  Zhishen Ge*a  

* Corresponding authors

a CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, China
E-mail: gezs@ustc.edu.cn

b Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Key Laboratory of Molecule-based Materials, College of Chemistry and Materials Science, Anhui Normal University, Wuhu, Anhui, China
E-mail: shzhluo@mail.ahnu.edu.cn

Abstract

The polymeric nanogels were constructed via host–guest interactions for dual pH-triggered multistage drug delivery, which showed tumor acidity-triggered nanogel reorganization into smaller nanoparticles for deep tissue penetration, high-efficiency cellular uptake, and intracellular endo-lysosomal pH-responsive drug release.

Graphical abstract: Dual pH-triggered multistage drug delivery systems based on host–guest interaction-associated polymeric nanogels

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C4CC03120B
Article type
Communication
Submitted
19 এপ্রিল 2014
Accepted
27 মে 2014
First published
02 জুন 2014

Chem. Commun., 2014,50, 7824-7827

Author version available

Download author version (PDF)

Permissions

Request permissions

Dual pH-triggered multistage drug delivery systems based on host–guest interaction-associated polymeric nanogels

M. Zan, J. Li, S. Luo and Z. Ge, Chem. Commun., 2014, 50, 7824 DOI: 10.1039/C4CC03120B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements