Themed collection Analyst Review Articles 2023
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DNA nanotechnology-based nucleic acid delivery systems for bioimaging and disease treatment
This review aims to introduce the development of DNA nanotechnology and recent advances of DNA nanostructure-based delivery systems for bioimaging, disease diagnosis, and therapeutic applications.
Analyst, 2024,149, 599-613
https://doi.org/10.1039/D3AN01871G
Noble metal-free SERS: mechanisms and applications
Surface-enhanced Raman scattering (SERS) is a very important tool in vibrational spectroscopy.
Analyst, 2024,149, 11-28
https://doi.org/10.1039/D3AN01669B
Small-molecule fluorescent probes for bioactive species in inflammatory disease: arthritis, pneumonia and hepatitis
The small-molecule fluorescent probes for bioactive species in inflammatory disease, mainly in arthritis, pneumonia and hepatitis are systematically summarized.
Analyst, 2023,148, 5303-5321
https://doi.org/10.1039/D3AN01289A
Recent development of nanotechnology-empowered antigen assay methods for the control of infectious diseases
This feature article summarizes current immunological assay methods for the detection of infectious diseases, highlighting the trend of future development.
Analyst, 2023,148, 2892-2900
https://doi.org/10.1039/D3AN00328K
Principles and applications of green fluorescent protein-based biosensors: a mini-review
An overview of the principles and applications of GFP-based biosensors.
Analyst, 2023,148, 2882-2891
https://doi.org/10.1039/D3AN00320E
Paper-based microfluidics in sweat detection: from design to application
Paper-based microfluidics offers a promising way to in situ sweat detection for non-invasive continuous monitoring. This passage reviews and prospects its development regarding materials, structuring, fabrication, modular design and application.
Analyst, 2023,148, 1175-1188
https://doi.org/10.1039/D2AN01818G
A minireview of recent developments in ozone detection using optical chemodosimeters
In this minireview, we have provided a summary of the recent advancements in optical chemodosimeters for ozone detection from 2009 to 2022.
Analyst, 2023,148, 954-965
https://doi.org/10.1039/D2AN01971J
A review related to MXene preparation and its sensor arrays of electronic skins
This review outlines the fabrication and function of MXene-based E-skins. Starting with the synthesis of pure MXenes, then walking through the steps of designing sensors, integrating electronic skin arrays and determining the various functions.
Analyst, 2023,148, 435-453
https://doi.org/10.1039/D2AN01143C
Progress in methods for the detection of viable Escherichia coli
This review described current methods for the detection of viable Escherichia coli, including culture-based methods, molecular approaches targeting DNA and RNA, bacteriophage-based methods, biosensors, and other emerging strategies.
Analyst, 2024,149, 1022-1049
https://doi.org/10.1039/D3AN01750H
A review on recent advances in assays for DNMT1: a promising diagnostic biomarker for multiple human cancers
The abnormal expression of human DNA methyltransferases (DNMTs) is closely related with the occurrence and development of a wide range of human cancers.
Analyst, 2024,149, 1002-1021
https://doi.org/10.1039/D3AN01915B
Advances in the synthesis of heteroatom-doped graphene-based materials and their application in sensors, adsorbents and catalysis
This review focuses on synthesis methods for N, B, P, and S co-doped graphenes and graphene-based composites and comprehensively discusses their recent applications in the fields of sensors, adsorbents and catalysis.
Analyst, 2023,148, 6201-6222
https://doi.org/10.1039/D3AN01401K
Genetically encoded protein sensors for metal ion detection in biological systems: a review and bibliometric analysis
Metal ions are indispensable elements in living organisms and are associated with regulating various biological processes.
Analyst, 2023,148, 5564-5581
https://doi.org/10.1039/D3AN01412F
Implantable microfluidics: methods and applications
This review comprehensively discusses the methods and applications of various microfluidic functionalities for implantable medical devices.
Analyst, 2023,148, 4637-4654
https://doi.org/10.1039/D3AN00981E
Application of ATP-based bioluminescence technology in bacterial detection: a review
With the development of new technologies for rapid and high-throughput bacterial detection, ATP-based bioluminescence technology is making progress.
Analyst, 2023,148, 3452-3459
https://doi.org/10.1039/D3AN00576C
Advances in deoxyribonucleic acid extraction techniques and point-of-care molecular diagnosis of foodborne pathogens
A conventional molecular assay-based point-of-care (POC) diagnostic test involves three major stages: deoxyribonucleic acid (DNA) extraction, amplification, and amplicon detection.
Analyst, 2023,148, 3153-3168
https://doi.org/10.1039/D3AN00045A
Sum frequency generation spectroscopy of fluorinated organic material-based interfaces: a tutorial review
Molecular interactions at interfaces have a significant effect on the wetting properties of surfaces on a macroscale.
Analyst, 2023,148, 2901-2920
https://doi.org/10.1039/D2AN02020C
Reagentless protein-based electrochemical biosensors
The creation of reagentless protein-based biosensors that are capable of monitoring molecular analytes directly in bodily fluids could revolutionize our understanding of biology and personalized health monitoring.
Analyst, 2023,148, 1930-1938
https://doi.org/10.1039/D3AN00341H
Advancements in microfluidics for skin cosmetic screening
Cosmetics can beautify the skin and assist the treatment of skin diseases. Some methods have been developed to replace animal experiments for cosmetic screening. The microfluidic skin chip is considered as a effective tool for in vitro tests.
Analyst, 2023,148, 1653-1671
https://doi.org/10.1039/D2AN01716D
Isothermal nucleic acid amplification technology in HIV detection
Nucleic acid testing for HIV plays an important role in the early diagnosis and monitoring of antiretroviral therapy outcomes in HIV patients and HIV-infected infants.
Analyst, 2023,148, 1189-1208
https://doi.org/10.1039/D2AN01813F
Recent advances in colorimetric sensors based on nanozymes with peroxidase-like activity
The research progress and applications of colorimetric sensors based on nanozymes with peroxidase-like activity.
Analyst, 2023,148, 487-506
https://doi.org/10.1039/D2AN01850K
Overview and considerations in bottom-up proteomics
This review provides a broad overview of mass spectrometry-based proteomics and highlights four developing areas: (1) protein inference, (2) alternative proteases, (3) sample-specific databases and (4) post-translational modification discovery.
Analyst, 2023,148, 475-486
https://doi.org/10.1039/D2AN01246D
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Cortisol sensing by optical sensors
Cortisol sensing using molecular sensors, aptamers and antibodies was explored, focusing on important analytical parameters.
Analyst, 2024,149, 989-1001
https://doi.org/10.1039/D3AN01801F
Carbon dots@noble metal nanoparticle composites: research progress report
Synthesis, characterization, and application of carbon dots@noble metal nanocomposites.
Analyst, 2024,149, 665-688
https://doi.org/10.1039/D3AN01580G
Activatable fluorescent probes for early diagnosis and evaluation of liver injury
With the increase in people's living standards, the number of patients suffering from liver injury keeps on increasing.
Analyst, 2024,149, 638-664
https://doi.org/10.1039/D3AN01631E
Advanced manufacturing of nanoparticle formulations of drugs and biologics using microfluidics
Scaled-up production of nano-formulations is challenging. Find out how microfluidic manufacturing simultaneously meets the requirements for quality and throughput.
Analyst, 2024,149, 614-637
https://doi.org/10.1039/D3AN01739G
Recent advances in optical biosensing and imaging of telomerase activity and relevant signal amplification strategies
Fluorometric, colorimetry, chemiluminescence, SERS, and dual-mode techniques for biosensing and imaging of telomerase are summerized. Relevant signal amplification strategies are included to provide ideas for exploration of more practicable methods.
Analyst, 2024,149, 290-303
https://doi.org/10.1039/D3AN01900D
The construction of dual-emissive ratiometric fluorescent probes based on fluorescent nanoparticles for the detection of metal ions and small molecules
Fluorescent nanoparticle (FNP)-based dual-emission ratiometric fluorescent probes (DRFP) are summarized as hybrid FNPs, single FNPs with intrinsic dual emission and target-induced new emission, and DRFPs based on auxiliary nanomaterials.
Analyst, 2024,149, 304-349
https://doi.org/10.1039/D3AN01711G
Optical sensors (optodes) for multiparameter chemical imaging: classification, challenges, and prospects
Seeing is believing - and optical sensors (optodes) are ideal tools to make chemistry visible in real time. Find out how technological and chemical advances enable multiparameter imaging of complex samples.
Analyst, 2024,149, 29-45
https://doi.org/10.1039/D3AN01661G
Surface-enhanced Raman spectroscopy as a powerful method for the analysis of Chinese herbal medicines
Surface-enhanced Raman spectroscopy has become a promising analytical method for raw material identification, bioactive component detection, adulterant characterization, and contaminant detection of Chinese herbal medicines.
Analyst, 2024,149, 46-58
https://doi.org/10.1039/D3AN01466E
State-of-the-art mass spectrometry imaging applications in biomedical research
Mass spectrometry imaging (MSI) has advanced from a niche technique to a widely applied spatial biology tool. This review highlights state-of-the-art MSI application in emerging and the six largest biomedical fields according to a set of criteria.
Analyst, 2023,148, 6161-6187
https://doi.org/10.1039/D3AN01495A
Surface plasmonic biosensors: principles, designs and applications
Recently, surface plasmon resonance (SPR) biosensors have been widely used in environmental monitoring, food contamination detection and diagnosing medical conditions due to their superior sensitivity, label-free detection and rapid analysis speed.
Analyst, 2023,148, 6146-6160
https://doi.org/10.1039/D3AN01241G
Plasmonic nanoparticle etching-based optical sensors: current status and future prospects
Plasmonic nanoparticles etching based label-free multicolorimetric sensors for biosensing and chemosensing applications
Analyst, 2023,148, 6188-6200
https://doi.org/10.1039/D3AN01244A
Nanomaterial-based biosensors for the detection of foodborne bacteria: a review
Ensuring food safety is a critical concern for the development and well-being of humanity, as foodborne illnesses caused by foodborne bacteria have increasingly become a major public health concern worldwide.
Analyst, 2023,148, 5790-5804
https://doi.org/10.1039/D3AN01554H
Breast tumor-on-chip: from the tumor microenvironment to medical applications
The breast tumor microenvironment, preclinical breast cancer models, fabrication methods, breast tumor-on-chip models, and applications are summarized.
Analyst, 2023,148, 5822-5842
https://doi.org/10.1039/D3AN01295F
Solvent-free strategies for developing latent fingermarks on paper: a review
Solvent free strategies for greener fingermark development.
Analyst, 2023,148, 5547-5563
https://doi.org/10.1039/D3AN01112G
Recent advances in aptamer-based biosensors for potassium detection
This review focuses on aptasensors for K+ detection, their signal generation strategies, their analytical performance, factors that affect their efficiency with major challenges and future prospects.
Analyst, 2023,148, 5340-5354
https://doi.org/10.1039/D3AN01053H
Recent advancements in nanomaterial based optical detection of food additives: a review
Food additives have become a critical component in the food industry.
Analyst, 2023,148, 5322-5339
https://doi.org/10.1039/D3AN01317K
Recent advances in deformation-assisted microfluidic cell sorting technologies
Deformation-assisted microfluidic cell sorting technologies according to how the deformability is characterized and the form in which the force acts.
Analyst, 2023,148, 4922-4938
https://doi.org/10.1039/D3AN01150J
Recent progress in quantitative technologies for the analysis of cancer-related exosome proteins
In this review, we summarize the recent advances in quantitative technologies for the analysis of cancer-related exosome proteins according to probe and sensing strategies and discuss the challenges and prospects of exosome protein detection methods.
Analyst, 2023,148, 4954-4966
https://doi.org/10.1039/D3AN01228J
Bioparameter-directed nanoformulations as MRI CAs enable the specific visualization of hypoxic tumour
The significant development of bioparameter-directed nanoformulations as MRI contrast agents for tumour diagnosis has been explained.
Analyst, 2023,148, 4967-4981
https://doi.org/10.1039/D3AN00972F
Genetically encoded fluorescence lifetime biosensors: overview, advances, and opportunities
This review outlines the overview, advances and opportunities of genetically encoded fluorescence lifetime biosensors, including their combination of lifetime imaging technique and lifetime analysis methods, applications and future consideration.
Analyst, 2023,148, 4939-4953
https://doi.org/10.1039/D3AN01201H
Wearable sensor platforms for real-time monitoring and early warning of metabolic disorders in humans
This review focus on highlights the recent advances in wearable sensor toward continues and monitoring the risk factors of metabolic syndrome (MS).
Analyst, 2023,148, 4616-4636
https://doi.org/10.1039/D3AN01085F
Modern microelectronics and microfluidics on microneedles
Possessing the attractive advantages of moderate invasiveness and high compliance, there is no doubt that microneedles (MNs) have been a gradually rising star in the field of medicine.
Analyst, 2023,148, 4591-4615
https://doi.org/10.1039/D3AN01045G
Lateral flow assay of pathogenic viruses and bacteria in healthcare
This review explores lateral flow assays for pathogenic viruses and bacteria, with a particular focus on methodologies, device components, construction methods, and applications.
Analyst, 2023,148, 4573-4590
https://doi.org/10.1039/D3AN00719G
High resolution mass spectrometry of respiratory viruses: beyond MALDI-ToF instruments for next generation viral typing, subtyping, variant and sub-variant identification
Review of the ability of high resolution mass spectrometry to detect, type, subtype and distinguish variants and sub-variants in virus clinical specimens with high confidence.
Analyst, 2023,148, 4263-4273
https://doi.org/10.1039/D3AN00953J
Ratiometric fluorescent probes for pH mapping in cellular organelles
The present review presents the advances in ratiometric pH probes development for ΔpHi mapping in cellular organelles. Furthermore, we highlight the major challenges in developing ratiometric probes that merit further research in the future.
Analyst, 2023,148, 4242-4262
https://doi.org/10.1039/D3AN00960B
Molecular imprinting-based ratiometric fluorescence sensors for environmental and food analysis
Environmental protection and food safety are closely related to the healthy development of human society; there is an urgent need for relevant analytical methods to determine environmental pollutants and harmful substances in food.
Analyst, 2023,148, 3971-3985
https://doi.org/10.1039/D3AN00483J
The importance of and difficulties involved in creating molecular probes for a carbon monoxide gasotransmitter
Commercial assay kits for H2S and NO have already been achieved, whereas the development of assay kits for CO remains challenging. This review scrutinizes the advancement, limitations, and prospects of CO molecular probes.
Analyst, 2023,148, 3952-3970
https://doi.org/10.1039/D3AN00849E
Advances in isothermal nucleic acid amplification methods for hepatitis B virus detection
A schematic diagram of the main methods for hepatitis B detection.
Analyst, 2023,148, 3708-3718
https://doi.org/10.1039/D3AN00700F
Mass spectrometry-based techniques for single-cell analysis
The cell is the most basic structural unit and plays a vital role in the function of an organism.
Analyst, 2023,148, 3690-3707
https://doi.org/10.1039/D3AN00370A
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Analytical chemistry of carbonyl compounds in indoor air
Carbonyl compounds relevant for the indoor environment are presented and analytical methods for determining their indoor air concentrations are discussed.
Analyst, 2023,148, 3432-3451
https://doi.org/10.1039/D3AN00822C
Magnetic nanoprobe-enabled lateral flow assays: recent advances
In recent years, magnetic nanoparticle sensor technologies have attracted considerable interest in the point-of-care-testing (POCT) field, especially in lateral flow immunoassays (LFIAs).
Analyst, 2023,148, 3418-3431
https://doi.org/10.1039/D3AN00044C
Greener chemistry in analytical sciences: from green solvents to applications in complex matrices. Current challenges and future perspectives: a critical review
More environment-friendly solvents in analytical chemistry are almost inevitable in both sample preparation and analysis to meet the high standards of sustainable chemistry and human welfare.
Analyst, 2023,148, 3130-3152
https://doi.org/10.1039/D3AN00498H
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Capillary-driven microfluidics: impacts of 3D manufacturing on bioanalytical devices
The advances in 3D capillary-driven microfluidics for bioanalytical devices, including design and surface chemistry, are presented. Classification of capillary flow control elements is presented based on two functional steps of stop and actuation.
Analyst, 2023,148, 2657-2675
https://doi.org/10.1039/D3AN00115F
Recent advances in metal–organic framework-based photoelectrochemical and electrochemiluminescence biosensors
This review summarizes recent advances on metal-organic frameworks for the applications in photoelectrochemical and electrochemiluminescence biosensors.
Analyst, 2023,148, 2200-2213
https://doi.org/10.1039/D3AN00222E
Concepts, electrode configuration, characterization, and data analytics of electric and electrochemical microfluidic platforms: a review
This review focuses on the theoretical concepts, electrode engineering, data analytics, and biomedical applications of electric and electrochemical microfluidic platforms, and highlights future directions for development.
Analyst, 2023,148, 1912-1929
https://doi.org/10.1039/D2AN02027K
Semiconductor quantum dots in photoelectrochemical sensors from fabrication to biosensing applications
Development of photoelectrochemical sensors interfaced with semiconductor quantum dots (QDs) as a promising approach for fabricating new photoelectrodes and photoelectrochemistry systems suitable for energy storage and biosensing applications.
Analyst, 2023,148, 1633-1652
https://doi.org/10.1039/D2AN01690G
Recent progress in homogeneous immunosensors based on fluorescence or bioluminescence using antibody engineering
Homogeneous immunosensors integrate the advantages of both biosensors and immunoassays; they include speed, high sensitivity, and accuracy.
Analyst, 2023,148, 1422-1429
https://doi.org/10.1039/D2AN01913B
Combining sensors and actuators with electrowetting-on-dielectric (EWOD): advanced digital microfluidic systems for biomedical applications
Typical forms of a combination of electrowetting-on-dielectric (EWOD) technology with sensing and other microfluidic manipulation techniques are reviewed from a technical perspective, including the purposes, significance, and biomedical applications.
Analyst, 2023,148, 1399-1421
https://doi.org/10.1039/D2AN01707E
Novel perspective for protein–drug interaction analysis: atomic force microscope
Proteins are major drug targets, and drug–target interaction identification and analysis are important factors for drug discovery. The properties of protein-drug interaction can be evaluated using AFM-based approaches.
Analyst, 2023,148, 454-474
https://doi.org/10.1039/D2AN01591A
Droplet microfluidics for CTC-based liquid biopsy: a review
We present a comprehensive review on droplet microfluidics for CTC-based liquid biopsy.
Analyst, 2023,148, 203-221
https://doi.org/10.1039/D2AN01747D
Advances in electrochemiluminescence for single-cell analysis
In this review, we summarise the device design strategies and the recent development in single-cell ECL analysis systems (sensing and imaging systems), as well as the modification of ECL probes through different functionalization strategies.
Analyst, 2023,148, 9-25
https://doi.org/10.1039/D2AN01159J
About this collection
This themed collection features recent review articles published in Analyst.