Themed collection Surface-enhanced Raman scattering

Welcome to this Analyst themed issue on surface-enhanced Raman scattering, guest edited by Duncan Graham, Richard van Duyne and Bin Ren.

Patrick Hendra looks back at the people and experiments that led to the discovery of SERS.

During the past few decades, thanks to silicon nanomaterials’ outstanding properties, different dimensional silicon nanostructures have been employed for designing and fabricating high-performance surface-enhanced Raman scattering (SERS) sensors for chemical and biological detection.

Fluctuating single sp² carbon clusters at single hotspots of silver nanoparticle dimers investigated by surface-enhanced Raman scattering (SERS), indicating that SERS has become an ultrasensitive tool for clarifying molecular functions on plasmonic metal nanoparticles (NPs).

Surface-enhanced Raman spectroscopy offers ultra-sensitive vibrational fingerprinting within biological cells.

The SERRS spectra of heme are influenced by structural changes, orientation, and selective adsorption on the Ag surface.

SERS active nanoparticles were labeled with a reporter molecule and conjugated with anti-EpCAM antibodies.

SERS experiments performed with the substrate immersed in liquid solutions are subjected to a temporal drift in the Raman signal intensity. This effect could have a negative impact on in situ quantitative chemical analysis.

Using Surface Enhanced Raman Spectroscopy to measure cell death caused by radiation in a 3D model of prostate cancer.

A single Au nanoparticle (NP) with a diameter of 5 nm was transferred to the end of a Si-tip through a picking process, and an Ag shell with a controlled thickness was formed on the Au core.

1550 nm SERS nanotags have been developed to provide effective SERS with picomolar detection limits when excited with a retina-safe laser.

Highly swellable polymer films doped with Ag nanoparticle aggregates (poly-SERS films) have been used to record very high signal : noise ratio, reproducible surface-enhanced resonance Raman (SERRS) spectra of in situ dried ink lines and their constituent dyes using both 633 and 785 nm excitation.

Comparison of the applicability and accuracy of FT-IR, Raman and SERS, as physicochemical whole organism fingerprinting approaches, for differentiation of a range of microbial samples.

Aminoglycoside antibiotics are used in the treatment of infections caused by Gram-negative bacteria, and are often dispensed only in severe cases due to their adverse side effects.

A SERS-enabled micro-chamber was constructed for reliable and pretreatment-free detection of NO₂⁻ based on a pH and laser irradiance-dependent diazotization.

Designing substrate-less plasmonic metacrystals for the multiplex ultratrace detection of analytes from both organic and aqueous phases.

Mesoporous silica-coated gold nanorods (AuNR@MS) act as a colloidally stable Raman sensing platform with a built-in analyte size cutoff.

The tether length of Nile Blue impacts molecular orientation leading to unique SERS spectroelectrochemistry.

A SERRS-based assay for thyrotropin-releasing hormone quantification coupled with the azo reaction was proposed with simplicity, rapidness, selectivity and ultrahigh sensitivity.

Multifunctional composite nanoprobes, Ag–Magnetite and Au–Magnetite, were manipulated in fibroblast cells and characterized using SERS, LA-ICP-MS, and nanotomography.

The electrochemical oxidation and reduction of riboflavin is detected and characterized by SERS.

Quantitative uranyl detection using surface-enhanced Raman scattering and functionalized gold nanostars.

Surface-enhanced Raman scattering (SERS) microscopy is an emerging imaging technique for tissue-based cancer diagnostics.

Unraveling the role played by the surface chemistry of silver colloids in the direct SERS analysis of DNA.

Based on the bianalyte method, time-dependent surface-enhanced Raman spectrosopy (SERS) spectra were applied to observe and study the competitive adsorption of bipyridine isomerides 2,2′-bpy and 4,4′-bpy.

Production of gold nanoparticle (AuNP) surface-enhanced Raman spectroscopy (SERS) nanoprobes requires replicable aggregation to produce multimers with high signal intensity.