Scientific workflow managers in metabolomics: an overview
Metabolomics workflows for data processing reproducibility and accelerated clinical deployment.
Precision medicine, bioanalytics and nanomaterials: toward a new generation of personalized portable diagnostics
The customization of disease treatment focused on genetic, environmental and lifestyle factors of individual patients, including tailored medical decisions and treatments, is identified as precision medicine.
Raman spectroscopy for rapid intra-operative margin analysis of surgically excised tumour specimens
A review of the progress and remaining challenges to the application of Raman spectroscopy for intraoperative margin analysis in cancer.
Towards precision medicine: the role and potential of protein and peptide microarrays
Techniques to comprehensively analyze protein signatures are pivotal to unravel disease mechanisms, develop novel biomarkers and targeted therapies. In this frame, protein and peptide microarrays can play a major role in fuelling precision medicine.
Paper
Determination of the concentration range for 267 proteins from 21 lots of commercial human plasma using highly multiplexed multiple reaction monitoring mass spectrometry
Multiple reaction monitoring (MRM) is a key tool for biomarker validation and the translation of potential biomarkers into the clinic.
Rapid, quantitative therapeutic screening for Alzheimer's enzymes enabled by optimal signal transduction with transistors
Commercially sourced silicon field-effect transistors enable sensitive measurements of small therapeutic molecules that regulate enzymes implicated in Alzheimer's disease.
Label-free counting of affinity-enriched circulating tumor cells (CTCs) using a thermoplastic micro-Coulter counter (μCC)
A micro-Coulter Counter (μCC) with simple and low cost fabrication process was developed and integrated with a circulating tumor cell (CTC) selection chip, providing label-free cell counting for CTC analysis.
Vibrational spectroscopy as a powerful tool for follow-up immunoadsorption therapy treatment of dilated cardiomyopathy – a case report
Treatment of dilated cardiomyopathy (DCM) – a leading cardiomyopathy condition – was followed over almost one year using Raman and IR absorption spectroscopy.
Engineering anisotropic cardiac monolayers on microelectrode arrays for non-invasive analyses of electrophysiological properties
Engineering cardiac tissues with physiological architectural and mechanical properties on microelectrode arrays enables long term culture and non-invasive collection of electrophysiological readouts.
CARS-imaging guidance for fs-laser ablation precision surgery
Ultrafast optical tools for disease diagnostics and precision surgery.
Single droplet detection of immune checkpoints on a multiplexed electrohydrodynamic biosensor
A nanofluidic mixing-enhanced biosensor enables parallel detection of soluble PD-1, PD-L1, and LAG-3 immune checkpoints in minute liquid biopsy samples.
Expression pattern of androgen receptors, AR-V7 and AR-567es, in circulating tumor cells and paired plasma-derived extracellular vesicles in metastatic castration resistant prostate cancer
Androgen-receptor splice variant 7 (AR-V7) is a highly promising liquid biopsy predictive biomarker showing primary or acquired resistance to novel androgen receptor signaling inhibitors in metastatic castration resistant prostate cancer (mCRPC).
Metabolomics for improved treatment monitoring of phenylketonuria: urinary biomarkers for non-invasive assessment of dietary adherence and nutritional deficiencies
Improved treatment monitoring of PKU patients: urinary biomarkers of dietary adherence and nutritional status.
SERS-based immunoassay using gold-patterned array chips for rapid and sensitive detection of dual cardiac biomarkers
A gold-patterned array platform has been developed for the ultrasensitive SERS-based detection of cTnI and CK-MB.
Microdistribution and quantification of the boron neutron capture therapy drug BPA in primary cell cultures of human glioblastoma tumour by NanoSIMS
The ability of secondary ion mass spectrometry (SIMS) to provide high sensitivity imaging of elements and small-medium mass molecules in biological tissues and cells, makes it a very powerful tool for drug distribution studies.
Multiplex isolation and profiling of extracellular vesicles using a microfluidic DICE device
We present a simple strategy to immobilize and analyze extracellular vesicles for multiple markers on a microfluidic device, called DICE.
A novel “AIE + ESIPT” near-infrared nanoprobe for the imaging of γ-glutamyl transpeptidase in living cells and the application in precision medicine
Novel near-infrared nanoprobe for detecting GGT in HepG2 cells and imaging in liver tumour tissue, satisfying for the need for clinical measure of GGT level.
An electrochemical scaffold sensor for rapid syphilis diagnosis
The faster a disease is diagnosed, the sooner treatment can be initiated, motivating a drive to replace standard laboratory techniques with point-of-care technology. Here we describe the development of an E-DNA sensor for the rapid measurement of anti-syphilis antibodies.
Ultrasensitive detection of lung cancer-associated miRNAs by multiple primer-mediated rolling circle amplification coupled with a graphene oxide fluorescence-based (MPRCA-GO) sensor
MPRCA-GO sensor can detect low amount of miRNAs, which are biomarkers in cancer diagnosis.
A new method using machine learning for automated image analysis applied to chip-based digital assays
An automated machine learning based method for image processes applied to digital assays.
About this collection
A collection of papers and reviews on bioanalytical tools for enabling precision medicine. The field of healthcare continues to move from the inefficient, one-size-fits-all-patients medicine of today, toward the data-driven and personalised medicine of tomorrow. Articles in this collection cover bioanalytical tools for enabling precision medicine, including imaging, spectroscopy, machine learning and miniaturised technologies on both solid tumours and liquid biopsy samples. The focus of this collection is not limited to cancer but is relevant to other diseases such as cystic fibrosis, diabetes and infectious diseases.
This collection is co-guest edited by Analyst Advisory Board member Professor Steven Soper (The University of Kansas, Lawrence, USA) and Professor Andrew Godwin (Director, Molecular Oncology, The University of Kansas Medical Center, USA).