Diastereoselective palladium-catalyzed functionalization of prochiral C(sp3)–H bonds of aliphatic and alicyclic compounds

Srinivasarao Arulananda Babu, Yashika Aggarwal, Pooja Patel and Radha Tomar

Chem. Commun., 2022, 58, 2612
DOI: 10.1039/D1CC05649B

Photocatalytic remote alkenylation of hydroxamides with enamides: synthesis of trisubstituted enamides via a radical pathway

Yu-Ting Wang, Xiao Zou, Peng-Cheng Xu, Dai-Xiang Chen, Yue Zhang, Sheng-Hu Yan and Hang-Dong Zuo

Org. Biomol. Chem., 2025, 23, 7914
DOI: 10.1039/D5OB01116G

Pd(ii)-catalyzed cyclization of 2-methyl aromatic ketones with maleimides through weak chelation assisted dual C–H activation

Gouranga Naskar and Masilamani Jeganmohan

Chem. Commun., 2024, 60, 6284
DOI: 10.1039/D4CC01651C

Construction of carbazole-based unnatural amino acid scaffolds via Pd(ii)-catalyzed C(sp3)–H functionalization

Ramandeep Kaur, Shefali Banga and Srinivasarao Arulananda Babu

Org. Biomol. Chem., 2022, 20, 4391
DOI: 10.1039/D2OB00658H

Ligand-enabled enantio- and site-selective remote C–H arylation of 2-(2-phenpropyl)pyridine derivatives

Dai-Yu Li, Jin-Ping Li, Shunsuke Yabu, Li-Sheng Wang, Hirofumi Sato, Masahiro Higashi, Yoichiro Kuninobu and Hong-Liang Li

Org. Chem. Front., 2025, 12, 2232
DOI: 10.1039/D4QO02236J

Selective 1,2-insertion of carbodiimides and substrate-divergent silyl group migration at 1-metallacyclobuta-2,3-dienes

Xinzhe Shi, Sihan Li, Anke Spannenberg, Fabian Reiß and Torsten Beweries

Inorg. Chem. Front., 2023, 10, 3584
DOI: 10.1039/D3QI00449J

Photocatalytic redox-neutral reaction of γ-indolyl α-keto esters

Man Wang, Ming Li, Long Zhang, Ran Song, Daoshan Yang and Jian Lv

Org. Chem. Front., 2022, 9, 1875
DOI: 10.1039/D1QO01890F

The Difference in Ir-Catalyzed C(sp2)–H and C(sp3)–H Bond Activation Assisted by a Directing Group: Cyclometalation via Cis- or Trans-Chelation?

Ling-Qi Meng, Jian-Sen Wang, Xiao-Xia You, Rong-Lin Zhong, Feng-Wei Gao and Zhong-Min Su

Inorg. Chem., 2024, 63, 17626
DOI: 10.1021/acs.inorgchem.4c02432

Direct site-selective C(sp³)–H functionalization of unprotected non-activated alcohols

V. Aggarwal, A. Kachore, E. Bala, H. Singh, S. Malik, M. Selvaraj, M. A. Assiri, P. K. Verma and U. Sharma

RUSS CHEM REV, 2024, 93, RCR5123
DOI: 10.59761/RCR5123

Nickel-Catalyzed Decarbonylative Reductive Alkylation of Aroyl Fluorides with Alkyl Bromides

Qiang Chen, Jingwen You, Tian Tian, Zhenyao Li, Myuto Kashihara, Hiroki Mori and Yasushi Nishihara

Org. Lett., 2022, 24, 9259
DOI: 10.1021/acs.orglett.2c03823

Diboron(4)‐Catalyzed Remote [3+2] Cycloaddition of Cyclopropanes via Dearomative/Rearomative Radical Transmission through Pyridine

Ming Xu, Zhijun Wang, Zhaohui Sun, Yizhao Ouyang, Zhengwei Ding, Tao Yu, Liang Xu and Pengfei Li

Angewandte Chemie, 2022, 134
DOI: 10.1002/ange.202214507

Palladium-Catalyzed Site-Selective [5 + 1] Annulation of Aromatic Amides with Alkenes: Acceleration of β-Hydride Elimination by Maleic Anhydride from Palladacycle

Qiyuan He, Ken Yamazaki, Yusuke Ano and Naoto Chatani

ACS Catal., 2022, 12, 1595
DOI: 10.1021/acscatal.1c05675

Overcoming the Challenges toward Selective C(6)–H Functionalization of 2-Pyridone with Maleimide through Mn(I)-Catalyst: Easy Access to All-Carbon Quaternary Center

Smruti Ranjan Mohanty, Namrata Prusty, Shyam Kumar Banjare, Tanmayee Nanda and Ponneri C. Ravikumar

Org. Lett., 2022, 24, 848
DOI: 10.1021/acs.orglett.1c04121

Palladium catalyzed ortho-C(sp2)–H activation/cyclization of aryl amines assisted by imine and vinylacetic acid

Xiangwen Tan, Yaru Jing, Jiahao Wu, Jiatian Li, Zhenjie Yang, Wanqing Wu, Zhuofeng Ke and Huanfeng Jiang

Nat Commun, 2024, 15
DOI: 10.1038/s41467-024-54018-2

Transition‐Metal‐Free Methods for the Remote C−H Bond Functionalization of Cyclic Amines

Weijie Chen, Xi Cao and Xiaoyu Yang

Asian J Org Chem, 2023, 12
DOI: 10.1002/ajoc.202200547

Expanding the Utility of Inexpensive Pyridine‐N‐oxide Directing Group for the Site‐selective sp2/sp3γ‐C−H and sp2δ‐C−H Functionalization of Carboxamides

Radha Tomar, Amit Kumar, Arup Dalal, Debabrata Bhattacharya, Prabhakar Singh and Srinivasarao Arulananda Babu

Asian J Org Chem, 2022, 11
DOI: 10.1002/ajoc.202200311

Ligand-Promoted Remote γ-C(sp3)–H Chlorination and Bromination of Alcohols

Yang-Yang Tu, Jun Luo and Chao Jiang

J. Org. Chem., 2025, 90, 2443
DOI: 10.1021/acs.joc.4c03031

Recent Progress in Direct Catalytic C(sp3)—H Silylation Reactions

Yi Cheng, Rongjing Hu, Xiaoqi Chen, Hao Yang, Xiaokang Niu and Lei Yang

Chinese Journal of Organic Chemistry, 2022, 42, 323
DOI: 10.6023/cjoc202109017

Transition‐Metal‐Catalyzed Remote C(sp3)−H Functionalization Of Carboxylic Acid And Its Derivatives

M. Shahid, Vijay Basavaraj Banakar, Pothapragada S. K. Prabhakar Ganesh and Purushothaman Gopinath

Asian J Org Chem, 2022, 11
DOI: 10.1002/ajoc.202200184

Rhodium‐Catalyzed C(sp3)–H Arylation of 8‐Methylquinolines with Arylsilanes

Lin Li, Haidong Liu, Yupeng Qian, Guohong Shen, Yun Shi, Jiajie Du and Haiqing Luo

Chin. J. Chem., 2024, 42, 2627
DOI: 10.1002/cjoc.202400429

Transition-metal-catalyzed site-selective γ- and δ-C(sp3)–H functionalization reactions

Bijin Li, Mazen Elsaid and Haibo Ge

Chem, 2022, 8, 1254
DOI: 10.1016/j.chempr.2022.04.018

Synthesis of Triaryl‐Substituted Acyclic Olefins via Palladium‐Catalyzed γ‐C(sp3)‐H Diarylation of 2‐(2‐Phenylpropyl)pyridine Derivatives

Jin‐Ping Li, Zhi‐Jing Guo, Jun‐Feng Wang, Li‐Sheng Wang, Jun Jiang and Hong‐Liang Li

Asian J Org Chem, 2025
DOI: 10.1002/ajoc.202500564

Ru‐, Rh‐ and Ir‐Catalyzed Enantioselective sp3C−H Functionalization

Ramandeep Kaur and Nidhi Jain

Chemistry An Asian Journal, 2022, 17
DOI: 10.1002/asia.202200944

Utility of 4‐Amino‐2,1,3‐benzothiadiazole Directing Group in the Pd(II)‐catalyzed Arylation of γ‐C−H Bonds of Carboxamides and β‐C‐H Bonds of Amino Acid Carboxamides

Narendra Bisht, Srinivasarao Arulananda Babu and Radha Tomar

Asian J Org Chem, 2022, 11
DOI: 10.1002/ajoc.202200589

Pd‐Catalyzed δ‐C(sp3)−H Thiolation of Amino Acid Derivatives

Andrés García‐Viada, Celia Sánchez‐González, Mario Martínez‐Mingo, Inés Alonso, Nuria Rodríguez and Juan C. Carretero

Adv Synth Catal, 2023, 365, 3973
DOI: 10.1002/adsc.202300808

Palladium‐Catalyzed PIDA‐Mediated δ‐C(sp3)−H Acetoxylation of Amino Acid Derivatives: Overriding Competitive Intramolecular Amination

Mario Martínez‐Mingo, Andrés García‐Viada, Daniel Sowa Prendes, Inés Alonso, Nuria Rodríguez, Ramón Gómez Arrayás and Juan C. Carretero

Angewandte Chemie, 2022, 134
DOI: 10.1002/ange.202209865

Ni-catalysed remote C(sp3)–H functionalization using chain-walking strategies

Ciro Romano and Ruben Martin

Nat Rev Chem, 2024, 8, 833
DOI: 10.1038/s41570-024-00649-4

Palladium-catalyzed oxidative arene C–H alkenylation reactions involving olefins

Asier Carral-Menoyo, Nuria Sotomayor and Esther Lete

Trends in Chemistry, 2022, 4, 495
DOI: 10.1016/j.trechm.2022.03.007

Palladium‐Catalyzed PIDA‐Mediated δ‐C(sp3)−H Acetoxylation of Amino Acid Derivatives: Overriding Competitive Intramolecular Amination

Mario Martínez‐Mingo, Andrés García‐Viada, Daniel Sowa Prendes, Inés Alonso, Nuria Rodríguez, Ramón Gómez Arrayás and Juan C. Carretero

Angew Chem Int Ed, 2022, 61
DOI: 10.1002/anie.202209865

Palladium‐Catalyzed Aerobic γ‐C(sp3)−H Lactamization Using a NOx‐based Redox Mediator

Kai Jia, Yang‐Yang Tu, Kam‐Hung Low, Jun Luo and Chao Jiang

Adv Synth Catal, 2024, 366, 3297
DOI: 10.1002/adsc.202400381

Manganese Catalyzed Site‐Selective Hydroxymethylation to 2‐Pyridones and Isoquinolones via C−H Activation

Anushka Rastogi, Mohit Kumar, Manoj Kumar Gangwar and Dipankar Koley

Adv Synth Catal, 2024
DOI: 10.1002/adsc.202400738

Computational Insights into Palladium-Catalyzed Site-Selective Anilide and Benzamide-Type [3+2] Annulation via Double C–H Bond Activation

Partha Mondal, Nilangshu Mandal, Arun K. Pal and Ayan Datta

J. Org. Chem., 2024, 89, 11371
DOI: 10.1021/acs.joc.4c01049

Nitrogen‐Centered Radical‐Directed C(sp3)−H Amination and Aminoalkylation Using (Diarylmethylene)amino Benziodoxolones

Kensuke Kiyokawa, Mari Sugimura, Megumi Abe, Daiki Wada, Hikaru Kaneba and Satoshi Minakata

ChemistryEurope, 2025
DOI: 10.1002/ceur.202500188

Diboron(4)‐Catalyzed Remote [3+2] Cycloaddition of Cyclopropanes via Dearomative/Rearomative Radical Transmission through Pyridine

Ming Xu, Zhijun Wang, Zhaohui Sun, Yizhao Ouyang, Zhengwei Ding, Tao Yu, Liang Xu and Pengfei Li

Angew Chem Int Ed, 2022, 61
DOI: 10.1002/anie.202214507

Regiodivergent sp3 C–H Functionalization via Ni-Catalyzed Chain-Walking Reactions

Jesus Rodrigalvarez, Franz-Lucas Haut and Ruben Martin

JACS Au, 2023, 3, 3270
DOI: 10.1021/jacsau.3c00617

Searching for New Four‐membered Palladacycles Derived from Anilines: Influence of the N‐Substituents in the Reaction Outcome

María‐Teresa Chicote, Delia Bautista, José Vicente and Isabel Saura‐Llamas

Eur J Inorg Chem, 2025, 28
DOI: 10.1002/ejic.202400719

Pd(II)‐Catalyzed, γ‐C(sp2)−H Alkoxylation in α‐Methylbenzylamine, Phenylglycinol, 3‐Amino‐3‐Phenylpropanol Toward Enantiopure Aryl Alkyl Ethers

Yashika Aggarwal, Rayavarapu Padmavathi, Prabhakar Singh and Srinivasarao Arulananda Babu

Asian J Org Chem, 2022, 11
DOI: 10.1002/ajoc.202200327

Fluorene and Fluorenone Unnatural Amino Acid Motifs via Diastereoselective Pd(II)‐Catalyzed sp3C−H Functionalization

Shefali Banga and Srinivasarao Arulananda Babu

Eur J Org Chem, 2024, 27
DOI: 10.1002/ejoc.202400272

Pd-Catalyzed Remote δ-C(sp2)–H Functionalization in Phenylalaninol: Expanding the Library of Phenylalaninols

Prabhakar Singh and Srinivasarao Arulananda Babu

Synthesis, 2023, 55, 4113
DOI: 10.1055/a-2147-3518