Anthony R. Carroll, Brent R. Copp, Tanja Grkovic, Robert A. Keyzers and Michèle R. Prinsep

Nat. Prod. Rep., 2024, 41, 162
DOI: 10.1039/D3NP00061C

Harnessing microbial co-culture to increase the production of known secondary metabolites

Yu-Zhen Li, Wan-Qi Zhang, Peng-Fei Hu, Qiong-Qiong Yang, István Molnár, Peng Xu and Bo-Bo Zhang

Nat. Prod. Rep., 2025, 42, 623
DOI: 10.1039/D4NP00052H

Differential modulation of α-pyrone production in co-cultures of Pestalotiopsis diospyri with three phytopathogenic fungi

Mustapha Ngaski Abubakar, Vitor de Souza Mazucato and Paulo Cezar Vieira

Arch Microbiol, 2026, 208
DOI: 10.1007/s00203-025-04650-3

Insights into the Chemical Diversity of Selected Fungi from the Tza Itzá Cenote of the Yucatan Peninsula

Carlos A. Fajardo-Hernández, Firoz Shah Tuglak Khan, Laura Flores-Bocanegra, Alejandra Prieto-Davó, Baojie Wan, Rui Ma, Mallique Qader, Rodrigo Villanueva-Silva, Anahí Martínez-Cárdenas, Marian A. López-Lobato, Shabnam Hematian, Scott G. Franzblau, Huzefa A. Raja, Rodolfo García-Contreras and Mario Figueroa

ACS Omega, 2022, 7, 12171
DOI: 10.1021/acsomega.2c00544

Approaches for the establishment of optimized co-culture system of multiple Trichoderma strains for culture metabolites highly effective in cucumber growth promotion

Hongyi Liu, Dazhi Hao, Yaqian Li, Xinhua Wang and Jie Chen

Front. Microbiol., 2022, 13
DOI: 10.3389/fmicb.2022.1020077

Genetic basis of Pseudonectria foliicola infection in humans and research on DKP-type natural products

Bingqian Zhuo, Na Bao, Xin Hong, Youqi Ji, Wei Xu and Yumei Ge

BMC Genomics, 2026, 27
DOI: 10.1186/s12864-026-12615-z

Diversity of African fungi, chemical constituents and biological activities

Bienvenu Tsakem, Joseph Tchamgoue, Rosemary Tonjock Kinge, Gesqiere Laure M. Tiani, Rémy Bertrand Teponno and Simeon F. Kouam

Fitoterapia, 2024, 178, 106154
DOI: 10.1016/j.fitote.2024.106154

(–)-Peniisocoumarin D, an unreported isocoumarin derivative isolated from the coculture of marine algicolous fungal strains Trichoderma flagellatum 12A1N and Fusarium proliferatum 1023F

Sheng-Tao Fang, Xu-Liang Hou, Yin-Ping Song, Ji-Xue Zou and Nai-Yun Ji

Natural Product Research, 2025, 1
DOI: 10.1080/14786419.2025.2567638

Bioactive Secondary Metabolites from Fungi of the Genus Cytospora Ehrenb. (Ascomycota)

Boris Yotta Kianfé, Joseph Tchamgoue, Abolfazl Narmani, Rémy Bertrand Teponno, André-Ledoux Njouonkou, Marc Stadler and Simeon Fogue Kouam

Molecules, 2023, 28, 3120
DOI: 10.3390/molecules28073120

Antifungal Metabolites Produced by the Coculture of Clonostachys rosea VDGF806 and Alternaria brassicicola

Wei‐Hua Wang, Xu‐Lu Luo, Xu‐Jie Qin, Jian‐Dong Tang, Si‐Da Xie, Kai‐Ze Shen, Guo‐Lei Zhu and Ping Zhao

Chemistry & Biodiversity, 2025, 22
DOI: 10.1002/cbdv.202502391

Anti-Biofilm Activity of Cocultimycin A against Candida albicans

Xiaohong Zhu, Anqi Wang, Yifan Zheng, Dan Li, Yuanjuan Wei, Maoluo Gan, Yan Li and Shuyi Si

IJMS, 2023, 24, 17026
DOI: 10.3390/ijms242317026

Regulation and induction of fungal secondary metabolites: a comprehensive review

Shaurya Prakash, Hemlata Kumari, Minakshi Sinha and Antresh Kumar

Arch Microbiol, 2025, 207
DOI: 10.1007/s00203-025-04386-0

Bioactive compounds and biomedical applications of endophytic fungi: a recent review

Amr H. Hashem, Mohamed S. Attia, Eslam K. Kandil, Mahmoud M. Fawzi, Ahmed S. Abdelrahman, Mohamed S. Khader, Mohamed A. Khodaira, Abdallah E. Emam, Mohamed A. Goma and Amer M. Abdelaziz

Microb Cell Fact, 2023, 22
DOI: 10.1186/s12934-023-02118-x

Citrisorbicillinol, an undescribed hybrid sorbicillinoid with osteogenic activity from Penicillium citrinum ZY-2

Ying Zhang, Jing Zhang, Qi Du, Xue Ming Wu, Yong Chen and Ren Xiang Tan

Fitoterapia, 2024, 173, 105836
DOI: 10.1016/j.fitote.2024.105836

The biocontrol potential of Trichoderma asperellum M1 against kiwifruit soft rot caused by Botryosphaeria dothidea

Qing Tan, Jieyu Li, Qian Zhou, Chenlan Li, Ziqin Bai, Geng Liu, Jieping Lin, Hui Luo and Wei Xue

Eur J Plant Pathol, 2026
DOI: 10.1007/s10658-026-03202-9

Recent Updates on the Secondary Metabolites from Fusarium Fungi and Their Biological Activities (Covering 2019 to 2024)

Prosper Amuzu, Xiaoqian Pan, Xuwen Hou, Jiahang Sun, Muhammad Abubakar Jakada, Eromosele Odigie, Dan Xu, Daowan Lai and Ligang Zhou

JoF, 2024, 10, 778
DOI: 10.3390/jof10110778

Lydicamycins induce morphological differentiation in actinobacterial interactions

Scott A. Jarmusch, Morten D. Schostag, Zhijie Yang, Jinglin Wang, Aaron J. C. Andersen, Tilmann Weber, Ling Ding and Jennifer F Biddle

Appl Environ Microbiol, 2025, 91
DOI: 10.1128/aem.00295-25

Discovery of Cladoescherins, Unusual Hybrid Metabolites Derived from a Fungal PKS and a Bacterial NRPS by Co-cultivation

Fang Li, Guiyang Wang, Shasha Li, Danni Zhang, Yu Chen, Wei Cheng and Maoluo Gan

J. Nat. Prod., 2025, 88, 2726
DOI: 10.1021/acs.jnatprod.5c01071

Weissella confusa XG-3 EPS: production intensification by co-culturing with Candida shehatae and partial characterization

Shuhan Yang, Shouqi Zhao, Yingying Ning and Dan Zhao

Preparative Biochemistry & Biotechnology, 2025, 55, 1295
DOI: 10.1080/10826068.2025.2504546

Fungal Coculture: Unlocking the Potential for Efficient Bioconversion of Lignocellulosic Biomass

Rafael Icaro Matos Vieira, Alencar da Silva Peixoto, Antonielle Vieira Monclaro, Carlos André Ornelas Ricart, Edivaldo Ximenes Ferreira Filho, Robert Neil Gerard Miller and Taísa Godoy Gomes

JoF, 2025, 11, 458
DOI: 10.3390/jof11060458

Exploring the secrets of marine microorganisms: Unveiling secondary metabolites through metagenomics

Shaoyu Wang, Xinyan Li, Weiqin Yang and Ranran Huang

Microbial Biotechnology, 2024, 17
DOI: 10.1111/1751-7915.14533

Exploring the modern approaches to enhance fungal endophyte-derived bioactive secondary metabolites

Palakjot Kour Sodhi, Tanveer Kour, Gursharan Kaur, Vijay Gahlaut, Santosh Kumar Rath, Vagish Dwibedi and Mahavir Joshi

3 Biotech, 2025, 15
DOI: 10.1007/s13205-025-04328-z

Insights into the Mycosphere Fungal Community and Its Association with Nucleoside Accumulation in Ophiocordyceps sinensis

Jianshuang Zhang, Wen Zhang, Xiaodan Wu, Weidi Fu, Chaoyun Yang and Nana Long

JoF, 2025, 11, 696
DOI: 10.3390/jof11100696

Anti-Tumor Secondary Metabolites Originating from Fungi in the South China Sea’s Mangrove Ecosystem

Yuyou Luo, Xiongming Luo, Tong Zhang, Siyuan Li, Shuping Liu, Yuxin Ma, Zongming Wang, Xiaobao Jin, Jing Liu and Xin Wang

Bioengineering, 2022, 9, 776
DOI: 10.3390/bioengineering9120776

Chromones Featuring a [6,6]-Spiroketal Moiety Produced by Coculture of the Endophytic Fungi Chaetomium virescens and Xylaria Grammica

Sitian Zhang, Nanjing Ding, Xinyu Zheng, Yuling Lu, Jiangchun Wei, Hanxiao Zeng, Weiguang Sun, Yuan Zhou, Ya Gao, Yonghui Zhang and Zhengxi Hu

J. Nat. Prod., 2025, 88, 36
DOI: 10.1021/acs.jnatprod.4c00773

Recent Advances in Chemistry and Bioactivities of Secondary Metabolites from the Genus Acremonium

Yuning Qin, Humu Lu, Xin Qi, Miaoping Lin, Chenghai Gao, Yonghong Liu and Xiaowei Luo

JoF, 2024, 10, 37
DOI: 10.3390/jof10010037

Induction of Three New Secondary Metabolites by the Co-Culture of Endophytic Fungi Phomopsis asparagi DHS-48 and Phomopsis sp. DHS-11 Isolated from the Chinese Mangrove Plant Rhizophora mangle

Jingwan Wu, Jingjing Ye, Juren Cen, Yuanjie Chen and Jing Xu

Marine Drugs, 2024, 22, 332
DOI: 10.3390/md22080332

Antagonistic activity of biocontrol agent Trichoderma spp. against Fusarium sp., the causal agent of Ananas comosus fruitlet rot

Lucas Martín Madrassi, Adriana Elizabet Alvarenga and María Celina Vedoya

BJ, 2024, 1, 1
DOI: 10.70099/BJ/2024.02.01.11

Metabolomic profiles of the liquid state fermentation in co-culture of Eurotium amstelodami and Bacillus licheniformis

Yunsheng Wang, Yincui Chen, Jiankang Xin, Xianjing Chen, Tingyan Xu, Jiefang He, Zhangxu Pan and Chuanbo Zhang

Front. Microbiol., 2023, 14
DOI: 10.3389/fmicb.2023.1080743

Metabolic picture of microbial interaction: chemical crosstalk during co-cultivation between three dominant genera of bacteria and fungi in medicinal plants rhizosphere

Moustafa M. Zohair, Wang Dongmei and Kuniyoshi Shimizu

Metabolomics, 2024, 20
DOI: 10.1007/s11306-024-02138-7

GNPS2 molecular networking reveals metabolic diversity in fungi isolated from protease-rich fruits

Vitor de Souza Mazucato, Winner Duque Rodrigues, Ludmilla Tonani, Marcia Regina von Zeska Kress and Paulo Cezar Vieira

Nat. Prod. Bioprospect., 2026, 16
DOI: 10.1007/s13659-026-00615-1

Co-Culture of Monascus purpureus and Aspergillus niger Isolated from Wuyi Hongqu to Enhance Monascus Pigments Production While Inhibiting Citrinin Production

Qin Yu, Xi Yuan and Fusheng Chen

JoF, 2025, 11, 829
DOI: 10.3390/jof11120829

The Potential Use of Fungal Co-Culture Strategy for Discovery of New Secondary Metabolites

Shuang Xu, Mengshi Li, Zhe Hu, Yilan Shao, Jialiang Ying and Huawei Zhang

Microorganisms, 2023, 11, 464
DOI: 10.3390/microorganisms11020464

A systematic approach to determine the outcome of the competition between two microbial species in bioreactor cocultures

Marcin Bizukojć, Tomasz Boruta and Anna Ścigaczewska

Antonie van Leeuwenhoek, 2025, 118
DOI: 10.1007/s10482-024-02035-y

Marine Natural Products in Inflammation‐Related Diseases: Opportunities and Challenges

Tao Zhang, Zijun Ouyang, Yueran Zhang, Haiyan Sun, Lingdong Kong, Qiang Xu, Jiao Qu and Yang Sun

Medicinal Research Reviews, 2025, 45, 1375
DOI: 10.1002/med.22109

Metabolomics-Guided Discovery of New Dimeric Xanthones from Co-Cultures of Mangrove Endophytic Fungi Phomopsis asparagi DHS-48 and Phomopsis sp. DHS-11

Jingwan Wu, Dandan Chen, Qing Li, Ting Feng and Jing Xu

Marine Drugs, 2024, 22, 102
DOI: 10.3390/md22030102

Recent advances in the use of Trichoderma-containing multicomponent microbial inoculants for pathogen control and plant growth promotion

László Kredics, Rita Büchner, Dóra Balázs, Henrietta Allaga, Orsolya Kedves, Gordana Racić, András Varga, Viktor Dávid Nagy, Csaba Vágvölgyi and György Sipos

World J Microbiol Biotechnol, 2024, 40
DOI: 10.1007/s11274-024-03965-5

Antagonistic activity of biocontrol agent Trichoderma spp. against Fusarium sp., the causal agent of Ananas comosus fruitlet rot

Lucas Martín Madrassi, Adriana Elizabet Alvarenga and María Celina Vedoya

BJ, 2024, 1, 1
DOI: 10.70099/BJ/2024.02.01.11

Chae-type cytochalasans from coculture of Aspergillus flavipes and Chaetomium globosum

Wenjing Wang, Junguo Huang, Liangxiu Liao, Xiaolong Yang, Chunmei Chen, Junjun Liu, Hucheng Zhu and Yonghui Zhang

Phytochemistry, 2024, 219, 113961
DOI: 10.1016/j.phytochem.2023.113961

Light-Induced Changes in Secondary Metabolite Production of Trichoderma atroviride

Kristina Missbach, Daniel Flatschacher, Christoph Bueschl, Jonathan Matthew Samson, Stefan Leibetseder, Martina Marchetti-Deschmann, Susanne Zeilinger and Rainer Schuhmacher

JoF, 2023, 9, 785
DOI: 10.3390/jof9080785

Computation-aided studies related to the induction of specialized metabolite biosynthesis in microbial co-cultures: An introductory overview

Tomasz Boruta

Computational and Structural Biotechnology Journal, 2023, 21, 4021
DOI: 10.1016/j.csbj.2023.08.011

Steroidal Adducts and Andrastin-Type Meroterpenoids from the Co-culture of Two Isodon Species-Associated Endophytic Fungi

Qiao-Peng Zhang, Kun Hu, Jian-Wei Tang, Xiao-Zheng Su, Xiao-Nian Li, Han-Dong Sun and Pema-Tenzin Puno

Synlett, 2025, 36, 1591
DOI: 10.1055/a-2526-0356

Bioactive Spirocyclic C‐Arylglycosides From the Fungal–Fungal Co‐Culture of Pestalotiopsis sp. and Nigrospora sp.

Meifang Wu, Yang Jin, Ying Chen, Ziqian Zeng, Wenbin Deng, Xiangdong Su and Yongbo Xue

Phytochemical Analysis, 2026, 37, 28
DOI: 10.1002/pca.70024

The Metabolite Profiling of Aspergillus fumigatus KMM4631 and Its Co-Cultures with Other Marine Fungi

Anton N. Yurchenko, Liliana E. Nesterenko, Roman S. Popov, Natalya N. Kirichuk, Viktoria E. Chausova, Ekaterina A. Chingizova, Marina P. Isaeva and Ekaterina A. Yurchenko

Metabolites, 2023, 13, 1138
DOI: 10.3390/metabo13111138

Gene Mining and Optimization of the Biosynthesis of Cannabidiol in Fusarium solani XG4-2

Jiale Cui, Wenbo Wu, Shun Zhang, Shang Li, Changyixin Xiao, Sujuan Cui, Zichang Lu, Mengran Zhan, Yuzhe Ren, Yang Xie, Yunfeng Zhang, Xiaozhou Luo and Jing Yin

J. Nat. Prod., 2025, 88, 1591
DOI: 10.1021/acs.jnatprod.5c00298

Co‐cultivation and Medium Optimization: A Strategy for Discovering Fungal‐derived Protease Inhibitors

Vitor de Souza Mazucato, Ludmilla Tonani, Marcia Regina von Zeska Kress, Adriano Defini Andricopulo, Gisele Barbosa, Renata Krogh, Leonardo Luiz Gomes Ferreira and Paulo Cezar Vieira

Chemistry & Biodiversity, 2025, 22
DOI: 10.1002/cbdv.202501135

Competitive exclusion of insect parasitic fungi: Enhanced metabolite biosynthesis in Beauveria bassiana and fatty acid production in Metarhizium robertsii during host coinfection

Kexin Liu, Gen Li, Siying Wu, Yang Zhang, Rong Zhou, Cheng Lv, Xingcheng Yue, Zhuoran Zhu, Tianzi Zhou, Bo Huang and Yulong Wang

Pesticide Biochemistry and Physiology, 2025, 214, 106561
DOI: 10.1016/j.pestbp.2025.106561

Tunable population dynamics in a synthetic filamentous coculture

Maurice Finger, Ana M. Palacio‐Barrera, Paul Richter, Ivan Schlembach, Jochen Büchs and Miriam A. Rosenbaum

MicrobiologyOpen, 2022, 11
DOI: 10.1002/mbo3.1324

Optimizing fermentation conditions for enhanced laccase production from Coriolus versicolor and its potential in degrading 2,4-dichlorophenol

Daiyi Zheng, Jiafeng Li, Zhiyuan Yu, Ping Wang, Qi Li and Linguo Zhao

Bioprocess Biosyst Eng, 2025, 48, 1817
DOI: 10.1007/s00449-025-03214-5

OSMAC Strategy: A promising way to explore microbial cyclic peptides

Yu Zhang, Li Feng, Xinya Hemu, Ning-Hua Tan and Zhe Wang

European Journal of Medicinal Chemistry, 2024, 268, 116175
DOI: 10.1016/j.ejmech.2024.116175

Enhanced bioremediation performance of Mn(Ⅱ) contamination in acidic wastewater by immobilized composite fungi on biochar

Jiashun Yin, Yanjie Niu, Zhengbo Yue, Xiao He, Junyi Gu and Jin Wang

Journal of Cleaner Production, 2026, 557, 148228
DOI: 10.1016/j.jclepro.2026.148228

Granulathiazole A protects 6-OHDA-induced Parkinson's disease from ferroptosis via activating Nrf2/HO-1 pathway

Luqi Kong, Yilan Wang, Zhou Tong, Rongrong Dai, Abdulla Yusuf, Lifen Du, Bin Liu, Zhiyong Huang and Linzhen Hu

Bioorganic Chemistry, 2024, 147, 107399
DOI: 10.1016/j.bioorg.2024.107399

Structurally diverse polyketides with herbicidal activity from the fungus Aspergillus aculeatus

Fei Liu, Shanshan Hong, Xiaoxia Gu, Qian Zhang, Qin Li, Weiguang Sun, Chunmei Chen, Yonghui Zhang and Hucheng Zhu

Phytochemistry, 2025, 240, 114631
DOI: 10.1016/j.phytochem.2025.114631

Natural product target identification of wheldone, a fungal metabolite, as a KIF11 inhibitor in ovarian cancer using the DiffPOP (Differential Protein Precipitation) method.

Manead Khin, Alejandra Cavazos Saldana, Manuel Rangel-Grimaldo, Huzefa A. Raja, Daniel Abegg, Julia Ekiert, Chang Liu, Sweta Misra, Kiira Ratia, Alexander Adibekian, Yu Gao, Samuel K. Kulp, Christopher C. Coss, Nicholas H. Oberlies and Joanna E. Burdette

Molecular & Cellular Proteomics, 2026, 101558
DOI: 10.1016/j.mcpro.2026.101558

Unlocking the magic in mycelium: Using synthetic biology to optimize filamentous fungi for biomanufacturing and sustainability

Charles Jo, Jing Zhang, Jenny M. Tam, George M. Church, Ahmad S. Khalil, Daniel Segrè and Tzu-Chieh Tang

Materials Today Bio, 2023, 19, 100560
DOI: 10.1016/j.mtbio.2023.100560

Characterization of pure mycelium materials from different mushroom-forming fungi

Jeroen G. van den Brandhof, Noortje Hansen, Chen Hou, Sander C. Broers, Martin Tegelaar and Han A. B. Wösten

Antonie van Leeuwenhoek, 2025, 118
DOI: 10.1007/s10482-025-02133-5

Antimicrobial and Anti-inflammatory Cyclic Tetrapeptides from the Co-cultures of Two Marine-Derived Fungi

Qin Li, Shasha Li, Shunwang Li, Xiaomeng Hao, Anqi Wang, Shuyi Si, Yanni Xu, Jicheng Shu and Maoluo Gan

J. Nat. Prod., 2024, 87, 365
DOI: 10.1021/acs.jnatprod.3c01115

The 2022 Fusarium Head Blight Outbreak in Ethiopia: Emerging Pathogens, Mixed Mycotoxins, and Interspecies Interactions

Liza M. DeGenring, Ashenafi Gemechu, Vahideh Rafiei, Karen Broz, Gizachew H. Regasa, Kiara Munsamy, Neriman Yilmaz, Yanhong Dong, Matthew N. Rouse and Milton T. Drott

Plant Disease, 2026, 110, 890
DOI: 10.1094/PDIS-01-25-0126-RE

Gradients of Aliveness and Engineering: A Taxonomy of Fungal Engineered Living Materials

Elise Elsacker, Jara Saluena Martin, Annah‐Ololade Sangosanya, Anouk Verstuyft, Aurélie Van Wylick and Eveline Peeters

Advanced Materials, 2026, 38
DOI: 10.1002/adma.202502728

Advances in Polysaccharide Production Based on the Co-Culture of Microbes

Wanrong Peng, Xueying Guo, Xinyi Xu, Dan Zou, Hang Zou and Xingyong Yang

Polymers, 2023, 15, 2847
DOI: 10.3390/polym15132847

Investigating the Stirred Tank Bioreactor Co-Cultures of the Secondary Metabolite Producers Streptomyces noursei and Penicillium rubens

Tomasz Boruta, Anna Ścigaczewska and Marcin Bizukojć

Biomolecules, 2023, 13, 1748
DOI: 10.3390/biom13121748

Unearthing “Sweet” Secrets: Recent Advances in Novel Actinomycetes-Derived Glycosides and Their Bioactivities

Haotian Wang, Meilin Zhu, Yixuan Zhang, Yajuan Cong, Lanying Li, Liang Zhu and Hao Liu

J. Agric. Food Chem., 2025, 73, 31700
DOI: 10.1021/acs.jafc.5c10978

Fungal Duel between Penicillium brasilianum and Aspergillus nomius Results in Dual Induction of Miktospiromide A and Kitrinomycin A

Michael S. Cowled, John A. Kalaitzis, Andrew Crombie, Rachel Chen, Nicolau Sbaraini, Ernest Lacey and Andrew M. Piggott

J. Nat. Prod., 2023, 86, 2398
DOI: 10.1021/acs.jnatprod.3c00593

New Anti-Hypoxic Metabolites from Co-Culture of Marine-Derived Fungi Aspergillus carneus KMM 4638 and Amphichorda sp. KMM 4639

Elena B. Belousova, Olesya I. Zhuravleva, Ekaterina A. Yurchenko, Galina K. Oleynikova, Alexandr S. Antonov, Natalya N. Kirichuk, Viktoria E. Chausova, Yuliya V. Khudyakova, Alexander S. Menshov, Roman S. Popov, Ekaterina S. Menchinskaya, Evgeny A. Pislyagin, Valery V. Mikhailov and Anton N. Yurchenko

Biomolecules, 2023, 13, 741
DOI: 10.3390/biom13050741

New frontiers of soil fungal microbiome and its application for biotechnology in agriculture

Maicon S. N. dos Santos, Lissara P. Ody, Bruno D. Kerber, Beatriz A. Araujo, Carolina E. D. Oro, João H. C. Wancura, Marcio A. Mazutti, Giovani L. Zabot and Marcus V. Tres

World J Microbiol Biotechnol, 2023, 39
DOI: 10.1007/s11274-023-03728-8

Harnessing Endophytic Fungi as a Sustainable Source of Novel Anticancer Agents: Opportunities, Challenges, and Future Directions

Elly Lowen, Simon E. Moulton, Enzo A. Palombo, Faith Kwa and Bita Zaferanloo

Molecules, 2026, 31, 693
DOI: 10.3390/molecules31040693

Exploring Diverse Bioactive Secondary Metabolites from Marine Microorganisms Using Co-Culture Strategy

Xiaolin Li, Huayan Xu, Yuyue Li, Shengrong Liao and Yonghong Liu

Molecules, 2023, 28, 6371
DOI: 10.3390/molecules28176371

Synergistic effects of Trichoderma and biochar on the biocontrol of two soil-borne phytopathogens in chickpeas

Ranjna Kumari, Vipul Kumar, Bhupendra Koul, Mohammad Abul Farah and Awdhesh Kumar Mishra

Front. Microbiol., 2025, 16
DOI: 10.3389/fmicb.2025.1583114

A mass spectrometry-based strategy for investigating volatile molecular interactions in microbial consortia: unveiling a Fusarium-specific induction of an antifungal compound

Antonio Azzollini, Barbara Sgorbini, Nicole Lecoultre, Carlo Bicchi, Jean-Luc Wolfender, Patrizia Rubiolo and Katia Gindro

Front. Microbiol., 2025, 15
DOI: 10.3389/fmicb.2024.1417919

Interspecific cross-talk: The catalyst driving microbial biosynthesis of secondary metabolites

Guihong Yu, Xiaoxuan Ge, Wanting Li, Linwei Ji and Song Yang

Biotechnology Advances, 2024, 76, 108420
DOI: 10.1016/j.biotechadv.2024.108420

Exploration of diverse secondary metabolites from Penicillium brasilianum by co-culturing with Armillaria mellea

Xiaoting Rong, Lihua Zhang, Wenni He, Zhe Guo, Hui Lv, Jinglin Bai, Liyan Yu, Lixin Zhang and Tao Zhang

Appl Microbiol Biotechnol, 2024, 108
DOI: 10.1007/s00253-024-13282-4

Inducible Volatile Chemical Signalling Drives Antifungal Activity of Trichoderma hamatum GD12 During Confrontation With the Pathogen Sclerotinia sclerotiorum

Gareth A. Thomas, József Vuts, David M. Withall, John C. Caulfield, John Sidda, Murray R. Grant, Christopher R. Thornton and Michael A. Birkett

Environ Microbiol Rep, 2025, 17
DOI: 10.1111/1758-2229.70192

Transcriptomics integrated with metabolomics reveal the competitive relationship between co-cultured Trichoderma asperellum HG1 and Bacillus subtilis Tpb55

Qingyu Li, Wei Lin, Xifen Zhang, Mei Wang, Yanfen Zheng, Xianbo Wang, Gui Gao, Yiqiang Li, Donglin Zhao and Chengsheng Zhang

Microbiological Research, 2024, 280, 127598
DOI: 10.1016/j.micres.2023.127598

Use of epigenetic regulation for the discovery of fungi derived cryptic natural product

Yuzheng Wang, Juan Guo, Jian-Jiang Zhong and Han Xiao

Process Biochemistry, 2024, 145, 32
DOI: 10.1016/j.procbio.2024.06.015

Production of secondary metabolites in stirred tank bioreactor co-cultures of Streptomyces noursei and Aspergillus terreus

Tomasz Boruta, Anna Ścigaczewska and Marcin Bizukojć

Front. Bioeng. Biotechnol., 2022, 10
DOI: 10.3389/fbioe.2022.1011220

Coculture of Coastal Macroalga-Epiphytic Trichoderma Fungi for Microalgal Algicide Production Highlighted by an Iodinated Terpenoid

Wei Zhang, Bing Liu, Zhen-Zhen Shi, Xin-Yue Ma, Xiu-Li Yin, Yin-Pin Song and Nai-Yun Ji

J. Nat. Prod., 2026, 89, 267
DOI: 10.1021/acs.jnatprod.5c01387

Hyperdiverse, bioactive, and interaction-specific metabolites produced only in co-culture suggest diverse competitors may fuel secondary metabolism of xylarialean fungi

Mario E. E. Franco, Megan N. Nickerson, Benjamin P. Bowen, Katherine Louie, Trent R. Northen, Jana M. U’Ren and Egon Anderson Ozer

mSystems, 2025, 10
DOI: 10.1128/msystems.00468-25

Bacterial secondary metabolites as resistance-modifying adjuvants: microbial origins, molecular mechanisms, and translational relevance

Victor Uchenna Chigozie and Charles Okechukwu Esimone

Front. Microbiol., 2026, 17
DOI: 10.3389/fmicb.2026.1779022

Untargeted Metabolomic to Access Chemical Differences Induced by Dual Endophyte Cultures Isolated from Euphorbia Umbellata

Amanda Santos Gusmão, João Carlos Silva Conceição, Stefane Moreira de Queiros Santos, Cecilia Lima Sampaio Pereira, Douglas Siqueira de Almeida Chaves, Karen de Jesus Nicácio, Daniela Aparecida Chagas‐Paula and Eliane de Oliveira Silva

Chemistry & Biodiversity, 2024, 21
DOI: 10.1002/cbdv.202400395

Harnessing the Reactivity of Duclauxin toward Obtaining hPTP1B1–400 Inhibitors

Enrique Aguilar-Ramírez, Valeria Reyes-Pérez, Carlos A. Fajardo-Hernández, Carlos D. Quezada-Suaste, Mario Carreón-Escalante, Verenice Merlin-Lucas, Beatriz Quiroz-García, Vinicio Granados-Soto and José Rivera-Chávez

J. Med. Chem., 2023, 66, 16222
DOI: 10.1021/acs.jmedchem.3c01594

Structures and Biological Activities of Secondary Metabolites from Daldinia spp.

Miao Yu, Shiji Chen, Jueying Shi, Weikang Chen, Yikang Qiu, Jing Lan, Shiyan Qu, Jiayi Feng, Ru Wang, Fangru Lin, Guolei Huang and Caijuan Zheng

JoF, 2024, 10, 833
DOI: 10.3390/jof10120833

Chaetoxylariones A–G: undescribed chromone-derived polyketides from co-culture of Chaetomium virescens and Xylaria grammica enabled via the molecular networking strategy

Sitian Zhang, Lianghu Gu, Yongtong Lin, Hanxiao Zeng, Nanjin Ding, Jiangchun Wei, Xiaoxia Gu, Chang Liu, Weiguang Sun, Yuan Zhou, Yonghui Zhang and Zhengxi Hu

Bioorganic Chemistry, 2024, 147, 107329
DOI: 10.1016/j.bioorg.2024.107329

New Antibacterial Dihydropyrones Induced by Co-Culture of Penicillium crustosum PRB-2 and Penicillium citrinum HDN11-186

Guihong Yu, Luning Zhou, Guangwei Wu and Dehai Li

J. Ocean Univ. China, 2024, 23, 216
DOI: 10.1007/s11802-023-5676-4

Targeted discovery of polyketides with antioxidant activity through integrated omics and cocultivation strategies

Cancan Wang, Chenjie Wang, Yanjun Liu, Yujie Yue, Xingyue Lu, Hong Wang, Youmin Ying, Jianwei Chen and John R. Spear

Appl Environ Microbiol, 2024, 90
DOI: 10.1128/aem.01603-24

Brassisterol A, a new ergosterol from co-cultivation of fungi attenuates neuroinflammation via targeting NLRP3/caspase-1/GSDMD pathway

Zhou Tong, Luqi Kong, Yuexing Zhang, Tianhui Hu, Rongrong Dai, Yilan Wang, Juan Ji, Zhiyong Huang and Linzhen Hu

Bioorganic Chemistry, 2024, 142, 106955
DOI: 10.1016/j.bioorg.2023.106955

Correlative metabologenomics of 110 fungi reveals metabolite–gene cluster pairs

Lindsay K. Caesar, Fatma A. Butun, Matthew T. Robey, Navid J. Ayon, Raveena Gupta, David Dainko, Jin Woo Bok, Grant Nickles, Robert J. Stankey, Don Johnson, David Mead, Kristof B. Cank, Cody E. Earp, Huzefa A. Raja, Nicholas H. Oberlies, Nancy P. Keller and Neil L. Kelleher

Nat Chem Biol, 2023, 19, 846
DOI: 10.1038/s41589-023-01276-8

Harnessing mycelium-based morphology of filamentous fungi in food biomanufacturing: Integrated advances, challenges, and future perspectives

Mengmeng Xu, Song Ming, Jiahao Cui, Yuxi Guo, Liting Zhao, Lei Chen, Guiyang Shi, Daming Fan and Zhongyang Ding

Trends in Food Science & Technology, 2026, 172, 105696
DOI: 10.1016/j.tifs.2026.105696

Hidden handshakes and hostilities: the two sides of fungal metabolites in plant-fungal interactions

Tatenda Justice Gunda, Nedhi Jasrotia, Ali Baba Eshawu, Natasha Sharma Awasthi, Hena Dhar, Vihang Vivek Ghalsasi, Aditi Thakur and Karnika Thakur

J. Plant Biochem. Biotechnol., 2026, 35, 80
DOI: 10.1007/s13562-026-01055-1

Unexpected Noremestrin with a Sulfur-Bearing 15-Membered Macrocyclic Lactone from Emericella sp. 1454

Yuchuan Chen, Tongmei Xiao, Shuyue Guo, Shanshan Chang, Xiaoming Xi, Bingjie Su, Tao Zhang, Liyan Yu, Wuli Zhao, Jingshuai Wu, Yan Li, Shuyi Si and Minghua Chen

Org. Lett., 2024, 26, 1
DOI: 10.1021/acs.orglett.3c02958

Enhancing chemical and biological diversity by co-cultivation

Denise M. Selegato and Ian Castro-Gamboa

Front. Microbiol., 2023, 14
DOI: 10.3389/fmicb.2023.1117559

Modern Trends in Natural Antibiotic Discovery

Anna A. Baranova, Vera A. Alferova, Vladimir A. Korshun and Anton P. Tyurin

Life, 2023, 13, 1073
DOI: 10.3390/life13051073

Dereplication-Guided Isolation of 3-O-Methylfunicone from Endophytic Fungal Co-culture and Its Inhibitory Effect on Phytophthora palmivora

Stéfane M. Q. Santos, Marcus V. A. Marques, Cecília L. S. Pereira, Henrique B. da Silva, Vinicius Palaretti, Viviani N. Takahashi, Sônia C. Oliveira Melo and Eliane O. Silva

ACS Omega, 2025, 10, 56587
DOI: 10.1021/acsomega.5c08920

Volatile communication in Actinobacteria: a language for secondary metabolism regulation

Lorena Cuervo, Carmen Méndez, José A. Salas, Carlos Olano and Mónica G. Malmierca

Microb Cell Fact, 2024, 23
DOI: 10.1186/s12934-024-02456-4

Wheldone Revisited: Structure Revision Via DFT-GIAO Chemical Shift Calculations, 1,1-HD-ADEQUATE NMR Spectroscopy, and X-ray Crystallography Studies

Manuel Rangel-Grimaldo, Cody E. Earp, Huzefa A. Raja, Jared S. Wood, Lina Mardiana, Kin Lok Ho, Alexandra Longcake, R. Thomas Williamson, Lukáš Palatinus, Michael J. Hall, Michael R. Probert and Nicholas H. Oberlies

J. Nat. Prod., 2024, 87, 2095
DOI: 10.1021/acs.jnatprod.4c00649

Endophytic Fungi Co-Culture: An Alternative Source of Antimicrobial Substances

Lucas Silva Tironi, Lucilene Bento Carletto, Eliane Oliveira Silva, Jan Schripsema and Jaine Honorata Hortolan Luiz

Microorganisms, 2024, 12, 2413
DOI: 10.3390/microorganisms12122413