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Complex in vitro models positioned for impact to drug testing in pharma: a review

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Comparative Analysis of Species-Specific Hepatocyte Function and Drug Effects in a Liver Microphysiological System PhysioMimix LC12 and 96-Well Plates

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Enhancing the Maturity and Diclofenac Metabolism Ability of Mesenchymal Stem Cell‐Derived Human Hepatocytes In Vitro Using Microfluidics Technology

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Visual electrophoresis titration model for portable enzyme inhibition assays by moving reaction boundary chip

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Liver-on-a-chip: Considerations, advances, and beyond

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A Novel Milli-fluidic Liver Tissue Chip with Continuous Recirculation for Predictive Pharmacokinetics Applications

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A primary human Gut/Liver microphysiological system to estimate human oral bioavailability

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Liver-on-chips for drug discovery and development

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Challenges and Opportunities for In Vitro–In Vivo Extrapolation of Aldehyde Oxidase-Mediated Clearance: Toward a Roadmap for Quantitative Translation

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Leveraging 3D cell culture and AI technologies for next-generation drug discovery

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Microfluidic Liver-on-a-Chip for Preclinical Drug Discovery

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Recent advances in environmental toxicology: Exploring gene editing, organ-on-a-chip, chimeric animals, and in silico models

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Human induced pluripotent stem cell–derived liver-on-a-chip for studying drug metabolism: the challenge of the cytochrome P450 family

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Bioengineered human gut-on-a-chip for advancing non-clinical pharmaco-toxicology

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Advances in Microfluidic Systems and Numerical Modeling in Biomedical Applications: A Review

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Navigating ADME profiling challenges in microphysiological systems: Evaluation of a liver-chip model for clearance prediction

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Computational and experimental advances in liver-on-a-chip technology for cancer research: a systematic review

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Advances and Challenges in 3D Modelling of Organ-on-a-Chip Devices with a Focus on the Glomerular Basement Membrane (GBM) and Tubular Systems: A Critical Review

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Evaluation of Metabolism of a Defined Pesticide Mixture through Multiple In Vitro Liver Models

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A scalable human liver-on-a-chip platform for predictive safety assessment

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Validation of HepG2/C3A Cell Cultures in Cyclic Olefin Copolymer Based Microfluidic Bioreactors

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Review on the application of metalloporphyrin catalysts as cytochrome P450 enzyme mimics in biomimetic modeling

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Potential integration of multiple organs-on-a-chip for comprehensive drug–drug interaction prediction

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Microfluidic Devices: A Tool for Nanoparticle Synthesis and Performance Evaluation

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Reproducibility and Robustness of a Liver Microphysiological System PhysioMimix LC12 under Varying Culture Conditions and Cell Type Combinations

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Construction of in vitro liver-on-a-chip models and application progress

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A hollow fiber membrane-based liver organoid-on-a-chip model for examining drug metabolism and transport

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In silico modeling and simulation of organ‐on‐a‐chip systems to support data analysis and a priori experimental design

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Organ‐on‐Chip: The Future of Nutrition Research in a One Health World

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The Combination of a Human Biomimetic Liver Microphysiology System with BIOLOGXsym, a Quantitative Systems Toxicology (QST) Modeling Platform for Macromolecules, Provides Mechanistic Understanding of Tocilizumab- and GGF2-Induced Liver Injury

James J. Beaudoin, Lara Clemens, Mark T. Miedel, Albert Gough, Fatima Zaidi, Priya Ramamoorthy, Kari E. Wong, Rangaprasad Sarangarajan, Christina Battista, Lisl K. M. Shoda, Scott Q. Siler, D. Lansing Taylor, Brett A. Howell, Lawrence A. Vernetti and Kyunghee Yang

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In vitro cellular model systems provide a promising alternative to animal experiments for studying the intestine-organ axis

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Current Research Trends in the Application of In Vitro Three-Dimensional Models of Liver Cells

Chawon Yun, Sou Hyun Kim and Young-Suk Jung

Pharmaceutics, 2022, 15, 54
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Computational prediction of the metabolites of agrochemicals formed in rats

Vincent-Alexander Scholz, Conrad Stork, Markus Frericks and Johannes Kirchmair

Science of The Total Environment, 2023, 895, 165039
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Evaluating Drug–Drug Interaction Risk Associated with Peptide Analogs Using advanced In Vitro Systems

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Utility of organ and organoids-on-chip based in vitro models in gene expression profiling: An overview

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The Current Status and Use of Microphysiological Systems by the Pharmaceutical Industry: The International Consortium for Innovation and Quality Microphysiological Systems Affiliate Survey and Commentary

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Can We Predict Clinical Pharmacokinetics of Highly Lipophilic Compounds by Integration of Machine Learning or In Vitro Data into Physiologically Based Models? A Feasibility Study Based on 12 Development Compounds

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Simulation of sildenafil metabolism using an electrochemical oxidation system

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Exploring the potential of liver microphysiological systems of varied configurations to model cholestatic chemical effects

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Synthetic human gonadal tissues for toxicology

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Liver-on-a-chip devices: the pros and cons of complexity

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Novel emerging cell and organoid systems for the study of drug metabolism and toxicity in humans

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DigiLoCS: A leap forward in predictive organ-on-chip simulations

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Digital twin-enhanced three-organ microphysiological system for studying drug pharmacokinetics in pregnant women

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