Michele Baldrighi, Davide Bartesaghi, Gabriella Cavallo, Michele R. Chierotti, Roberto Gobetto, Pierangelo Metrangolo, Tullio Pilati, Giuseppe Resnati and Giancarlo Terraneo

CrystEngComm, 2014, 16, 5897
DOI: 10.1039/C4CE00367E

Pharmaceutical cocrystals: walking the talk

Geetha Bolla and Ashwini Nangia

Chem. Commun., 2016, 52, 8342
DOI: 10.1039/C6CC02943D

Ionic co-crystals of racetams: solid-state properties enhancement of neutral active pharmaceutical ingredients via addition of Mg2+ and Ca2+ chlorides

Fabrizia Grepioni, Johan Wouters, Dario Braga, Saverio Nanna, Baptiste Fours, Gérard Coquerel, Geraldine Longfils, Sandrine Rome, Luc Aerts and Luc Quéré

CrystEngComm, 2014, 16, 5887
DOI: 10.1039/c4ce00409d

From molecular crystals to salt co-crystals of barbituric acid via the carbonate ion and an improvement of the solid state properties

Michele R. Chierotti, Katia Gaglioti, Roberto Gobetto, Dario Braga, Fabrizia Grepioni and Lucia Maini

CrystEngComm, 2013, 15, 7598
DOI: 10.1039/c3ce40938d

Improved solid-state stability of salts by cocrystallization between conjugate acid–base pairs

Sathyanarayana Reddy Perumalla and Changquan Calvin Sun

CrystEngComm, 2013, 15, 5756
DOI: 10.1039/c3ce40593a

From isomorphous to “anisomorphous” ionic co-crystals of barbituric acid upon dehydration and return

L. Maini, D. Braga, F. Grepioni, G. I. Lampronti, K. Gaglioti, R. Gobetto and M. R. Chierotti

CrystEngComm, 2016, 18, 4651
DOI: 10.1039/C6CE00566G

Combining API in a dual-drug ternary cocrystal approach

Lixing Song, Koen Robeyns, Nikolay Tumanov, Johan Wouters and Tom Leyssens

Chem. Commun., 2020, 56, 13229
DOI: 10.1039/D0CC05788F

Significant Expansion of the Solid State Landscape of Salicylic Acid Based on Charge-Assisted Hydrogen Bonding Interactions

Benyong Lou, Sathyanarayana R. Perumalla and Changquan Calvin Sun

Crystal Growth & Design, 2015, 15, 24
DOI: 10.1021/cg501496a

A proposal for coherent nomenclature of multicomponent crystals

Marlena Gryl, Marcin Kozieł and Katarzyna M. Stadnicka

Acta Crystallogr B Struct Sci Cryst Eng Mater, 2019, 75, 53
DOI: 10.1107/S2052520618015858

Making crystals with a purpose; a journey in crystal engineering at the University of Bologna

Dario Braga, Fabrizia Grepioni, Lucia Maini and Simone d'Agostino

IUCrJ, 2017, 4, 369
DOI: 10.1107/S2052252517005917

Ionic Cocrystals of Etiracetam and Levetiracetam: The Importance of Chirality for Ionic Cocrystals

Lixing Song, Oleksii Shemchuk, Koen Robeyns, Dario Braga, Fabrizia Grepioni and Tom Leyssens

Crystal Growth & Design, 2019, 19, 2446
DOI: 10.1021/acs.cgd.9b00136

Solution Cocrystallization: A Scalable Approach for Cocrystal Production

Nitin Pawar, Anindita Saha, Neelesh Nandan and Jose Parambil

Crystals, 2021, 11, 303
DOI: 10.3390/cryst11030303

Complexation: An Interesting Pathway for Combining Two APIs at the Solid State

Fucheng Leng, Oleksii Shemchuk, Koen Robeyns and Tom Leyssens

Pharmaceutics, 2022, 14, 1960
DOI: 10.3390/pharmaceutics14091960

Engineering Cocrystals of Poorly Water-Soluble Drugs to Enhance Dissolution in Aqueous Medium

Indumathi Sathisaran and Sameer Dalvi

Pharmaceutics, 2018, 10, 108
DOI: 10.3390/pharmaceutics10030108

Ionic Cocrystals of Pharmaceutical Compounds: Sodium Complexes of Carbamazepine

Amanda R. Buist and Alan R. Kennedy

Crystal Growth & Design, 2014, 14, 6508
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Enhancing the Solubility of 6-Mercaptopurine by Formation of Ionic Cocrystal with Zinc Trifluoromethanesulfonate: Single-Crystal-to-Single-Crystal Transformation

Jia Yao, Jia-Mei Chen, Yi-Bo Xu and Tong-Bu Lu

Crystal Growth & Design, 2014, 14, 5019
DOI: 10.1021/cg5005819

Salt and Ionic Cocrystalline Forms of Amides: Protonation of Carbamazepine in Aqueous Media.

Amanda R. Buist, David S. Edgeley, Elena A. Kabova, Alan R. Kennedy, Debbie Hooper, David G. Rollo, Kenneth Shankland and Mark J. Spillman

Crystal Growth & Design, 2015, 15, 5955
DOI: 10.1021/acs.cgd.5b01223

Multidrug co-crystals: towards the development of effective therapeutic hybrids

Rajesh Thipparaboina, Dinesh Kumar, Rahul B. Chavan and Nalini R. Shastri

Drug Discovery Today, 2016, 21, 481
DOI: 10.1016/j.drudis.2016.02.001

Pharmaceutical salts and cocrystals involving amino acids: A brief structural overview of the state-of-art

Anaëlle Tilborg, Bernadette Norberg and Johan Wouters

European Journal of Medicinal Chemistry, 2014, 74, 411
DOI: 10.1016/j.ejmech.2013.11.045

Folic Acid in the Solid State: A Synergistic Computational, Spectroscopic, and Structural Approach

Dario Braga, Laura Chelazzi, Fabrizia Grepioni, Lorenzo Maschio, Saverio Nanna and Paola Taddei

Crystal Growth & Design, 2016, 16, 2218
DOI: 10.1021/acs.cgd.6b00043

Pharmaceutical aspects of salt and cocrystal forms of APIs and characterization challenges

Paolo Cerreia Vioglio, Michele R. Chierotti and Roberto Gobetto

Advanced Drug Delivery Reviews, 2017, 117, 86
DOI: 10.1016/j.addr.2017.07.001

Ionic Cocrystals of Racemic and Enantiopure Histidine: An Intriguing Case of Homochiral Preference

Dario Braga, Lorenzo Degli Esposti, Katia Rubini, Oleksii Shemchuk and Fabrizia Grepioni

Crystal Growth & Design, 2016, 16, 7263
DOI: 10.1021/acs.cgd.6b01426

The Relevance of Crystal Forms in the Pharmaceutical Field: Sword of Damocles or Innovation Tools?

Dario Braga, Lucia Casali and Fabrizia Grepioni

IJMS, 2022, 23, 9013
DOI: 10.3390/ijms23169013

Molecular Salts of the Antidepressant Venlafaxine: An Effective Route to Solubility Properties Modifications

Floriana Spinelli, Elena Dichiarante, Marco Curzi, Stefano L. Giaffreda, Michele R. Chierotti, Roberto Gobetto, Federica Rossi, Laura Chelazzi, Dario Braga and Fabrizia Grepioni

Crystal Growth & Design, 2017, 17, 4270
DOI: 10.1021/acs.cgd.7b00606

Cocrystallization of Trimethoprim and Solubility Enhancement via Salt Formation

Qixuan Zheng, Daniel K. Unruh and Kristin M. Hutchins

Crystal Growth & Design, 2021, 21, 1507
DOI: 10.1021/acs.cgd.0c01197

The Future of Structural Chemistry Nucleates in the Present

Dario Braga

Israel Journal of Chemistry, 2017, 57, 101
DOI: 10.1002/ijch.201600049

Origin of Deteriorated Crystal Plasticity and Compaction Properties of a 1:1 Cocrystal between Piroxicam and Saccharin

Sayantan Chattoraj, Limin Shi, Miles Chen, Amjad Alhalaweh, Sitaram Velaga and Changquan Calvin Sun

Crystal Growth & Design, 2014, 14, 3864
DOI: 10.1021/cg500388s

Physical Stability Enhancement and Pharmacokinetics of a Lithium Ionic Cocrystal with Glucose

Naga Kiran Duggirala, Adam J. Smith, Łukasz Wojtas, R. Douglas Shytle and Michael J. Zaworotko

Crystal Growth & Design, 2014, 14, 6135
DOI: 10.1021/cg501310d

Understanding the Effects of Ionicity in Salts, Solvates, Co-Crystals, Ionic Co-Crystals, and Ionic Liquids, Rather than Nomenclature, Is Critical to Understanding Their Behavior

Steven P. Kelley, Asako Narita, John D. Holbrey, Keith D. Green, W. Matthew Reichert and Robin D. Rogers

Crystal Growth & Design, 2013, 13, 965
DOI: 10.1021/cg4000439

Salts and Co-Crystals of Gentisic Acid with Pyridine Derivatives: The Effect of Proton Transfer on the Crystal Packing (and Vice Versa)

Vladimir Stilinović and Branko Kaitner

Crystal Growth & Design, 2012, 12, 5763
DOI: 10.1021/cg301267h

Imazamox: A Quest for Polymorphic Modifications of a Chiral and Racemic Herbicide

Dario Braga, Laura Chelazzi, Fabrizia Grepioni, Saverio Nanna, Katia Rubini, Marco Curzi, Stefano Giaffreda, Heidi E. Saxell, Matthias Bratz and Tiziana Chiodo

Crystal Growth & Design, 2014, 14, 1430
DOI: 10.1021/cg4019025

Enabling the Tablet Product Development of 5-Fluorocytosine by Conjugate Acid Base Cocrystals

Sathyanarayana R. Perumalla, Shubhajit Paul and Changquan C. Sun

Journal of Pharmaceutical Sciences, 2016, 105, 1960
DOI: 10.1016/j.xphs.2016.04.006

New forms of old drugs: improving without changing

Sofia Domingos, Vânia André, Sílvia Quaresma, Inês C B Martins, M Fátima Minas da Piedade and Maria Teresa Duarte

Journal of Pharmacy and Pharmacology, 2015, 67, 830
DOI: 10.1111/jphp.12384

Hydrogen Bond Hierarchy: Persistent Phenol···Chloride Hydrogen Bonds in the Presence of Carboxylic Acid Moieties

Naga Kiran Duggirala, Geoffrey P. F. Wood, Addison Fischer, Łukasz Wojtas, Miranda L. Perry and Michael J. Zaworotko

Crystal Growth & Design, 2015, 15, 4341
DOI: 10.1021/acs.cgd.5b00628

Crystallizing Ionic Cocrystals: Structural Characteristics, Thermal Behavior, and Crystallization Development of a Piracetam-CaCl2 Cocrystallization Process

Lixing Song, Koen Robeyns and Tom Leyssens

Crystal Growth & Design, 2018, 18, 3215
DOI: 10.1021/acs.cgd.8b00352

Natural Antimicrobials Meet a Synthetic Antibiotic: Carvacrol/Thymol and Ciprofloxacin Cocrystals as a Promising Solid-State Route to Activity Enhancement

Oleksii Shemchuk, Simone d’Agostino, Cecilia Fiore, Vittorio Sambri, Silvia Zannoli, Fabrizia Grepioni and Dario Braga

Crystal Growth & Design, 2020, 20, 6796
DOI: 10.1021/acs.cgd.0c00900

Mechanochemical Synthesis of a Urea•Proline Cocrystal as Dairy Cattle Feed and Its Effect on Ruminal Degradation

Laura Contini, Diptajyoti Gogoi, Ana Carolina Fluck, Júlia Gomes Farias, Clinton Williams, Ranijt Thakuria, Jonas Baltrusaitis and Fabrizia Grepioni

ACS Sustainable Resour. Manage., 2025
DOI: 10.1021/acssusresmgt.5c00125

Novel lithium ionic cocrystals with benzoic acid derivatives and L-proline: Synthesis, X-ray structures, IR spectrums, DSC analysis, and water solubility

Yanping Li, Hua Chen, Jimin Lai, Xinlan Huang, Guangjian Leng, Haoran Zhang, Zehong Lin, Jitao Liu, Ercheng Xiao and Wei Xu

Journal of Molecular Structure, 2024, 1315, 138795
DOI: 10.1016/j.molstruc.2024.138795

Improving Lithium Therapeutics by Crystal Engineering of Novel Ionic Cocrystals

Adam J. Smith, Seol-Hee Kim, Naga K. Duggirala, Jingji Jin, Lukasz Wojtas, Jared Ehrhart, Brian Giunta, Jun Tan, Michael J. Zaworotko and R. Douglas Shytle

Mol. Pharmaceutics, 2013, 10, 4728
DOI: 10.1021/mp400571a

Piracetam and Oxiracetam Afford Molecular, Cocrystalline, and Ionic Cocrystalline Solid Solutions

Enrico Spoletti, Ting Wen, Fucheng Leng, Nathan Boukioud, Jason Carty Lacey, Shaza Darwish, Oleksii Shemchuk, Koen Robeyns, Tom Leyssens and Matteo Lusi

Crystal Growth & Design, 2025, 25, 6754
DOI: 10.1021/acs.cgd.5c00735

Maximising success in multidrug formulation development: A review

Oisin N. Kavanagh, Ahmad B. Albadarin, Denise M. Croker, Anne Marie Healy and Gavin M. Walker

Journal of Controlled Release, 2018, 283, 1
DOI: 10.1016/j.jconrel.2018.05.024

Isomorphous Salts of Anti-HIV Saquinavir Mesylate: Exploring the Effect of Anion-Exchange on Its Solid-State and Dissolution Properties

Cinira Fandaruff, Laura Chelazzi, Dario Braga, Silvia Lucia Cuffini, Marcos Antônio Segatto Silva, Jackson A. L. C. Resende, Elena Dichiarante and Fabrizia Grepioni

Crystal Growth & Design, 2015, 15, 5233
DOI: 10.1021/acs.cgd.5b00696

Creation of a ternary complex between a crown ether, 4-aminobenzoic acid and 3,5-dinitrobenzoic acid

Nicole D. Boardman, Tasnim Munshi, Ian J. Scowen and Colin C. Seaton

Acta Crystallogr B Struct Sci Cryst Eng Mater, 2014, 70, 132
DOI: 10.1107/S2052520613026036

Drug‑Drug and Drug‑Nutraceutical Cocrystal/Salt as Alternative Medicine for Combination Therapy: A Crystal Engineering Approach

Ranjit Thakuria and Bipul Sarma

Crystals, 2018, 8, 101
DOI: 10.3390/cryst8020101