Issue 16, 2024

Applications of nanotechnology in remodeling the tumour microenvironment for glioblastoma treatment

Abstract

With the increasing research and deepening understanding of the glioblastoma (GBM) tumour microenvironment (TME), novel and more effective therapeutic strategies have been proposed. The GBM TME involves intricate interactions between tumour and non-tumour cells, promoting tumour progression. Key therapeutic goals for GBM treatment include improving the immunosuppressive microenvironment, enhancing the cytotoxicity of immune cells against tumours, and inhibiting tumour growth and proliferation. Consequently, remodeling the GBM TME using nanotechnology has emerged as a promising approach. Nanoparticle-based drug delivery enables targeted delivery, thereby improving treatment specificity, facilitating combination therapies, and optimizing drug metabolism. This review provides an overview of the GBM TME and discusses the methods of remodeling the GBM TME using nanotechnology. Specifically, it explores the application of nanotechnology in ameliorating immune cell immunosuppression, inducing immunogenic cell death, stimulating, and recruiting immune cells, regulating tumour metabolism, and modulating the crosstalk between tumours and other cells.

Graphical abstract: Applications of nanotechnology in remodeling the tumour microenvironment for glioblastoma treatment

Article information

Article type
Review Article
Submitted
14 май 2024
Accepted
08 юли 2024
First published
09 юли 2024

Biomater. Sci., 2024,12, 4045-4064

Applications of nanotechnology in remodeling the tumour microenvironment for glioblastoma treatment

Y. Mu, Z. Zhang, H. Zhou, L. Ma and D. Wang, Biomater. Sci., 2024, 12, 4045 DOI: 10.1039/D4BM00665H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements