Issue 47, 2022

Effectiveness of 7-chloro-4-(phenylselanyl) quinoline in improving learning, short-term memory, and anxiety-like behaviors in a mimetic model of Parkinson's disease in Drosophila melanogaster

Abstract

Parkinson's disease (PD) presents symptoms based mainly on motor changes; however, psychomotor and non-motor manifestations, such as anxiety-like behavior, learning, and memory deficits, also have a relevant impact on the individual's quality of life. Recently, 7-chloro-4-(phenylselanyl) quinoline (4-PSQ) showed positive effects on motor and biochemical behavioral parameters in a model of PD, in Drosophila melanogaster. The present study aimed to evaluate the effects of 4-PSQ in the psychomotor and non-motor alterations in a mimetic model of PD induced by rotenone (ROT) in Drosophila melanogaster. Flies of both sexes with two days of age were used and divided into four groups: [1] control group, [2] 4-PSQ (25 μM) group, [3] ROT (500 μM) group, and [4] 4-PSQ (25 μM) + ROT (500 μM) group, exposed to a diet with ROT and/or 4-PSQ for seven days, according to each group. The open field and equilibrist test, aversive phototaxis suppression assay, light/dark exploration test, and the acetylcholinesterase (AChE) activity were performed. The treatment with 4-PSQ was effective in reversing the ROT-induced deficits in flies, improving spontaneous locomotor activity, learning, memory, and anxiety-like behavior. And the 4-PSQ was able to prevent the increase in the AChE activity in the head and body of flies exposed to ROT. The treatment with 4-PSQ was effective in the prevention of psychomotor and non-motor deficits in this mimetic model of PD, with effects possibly related to its anticholinesterase activity, associated with the multi-target action of 4-PSQ.

Graphical abstract: Effectiveness of 7-chloro-4-(phenylselanyl) quinoline in improving learning, short-term memory, and anxiety-like behaviors in a mimetic model of Parkinson's disease in Drosophila melanogaster

Supplementary files

Article information

Article type
Paper
Submitted
17 авг 2022
Accepted
29 окт 2022
First published
16 ное 2022

New J. Chem., 2022,46, 22539-22549

Effectiveness of 7-chloro-4-(phenylselanyl) quinoline in improving learning, short-term memory, and anxiety-like behaviors in a mimetic model of Parkinson's disease in Drosophila melanogaster

S. D. F. Couto, S. M. Araujo, V. C. Bortolotto, M. M. M. Dahleh, E. A. S. Musachio, F. C. Pinheiro, L. C. Romio, M. do Sacramento, D. Alves and M. Prigol, New J. Chem., 2022, 46, 22539 DOI: 10.1039/D2NJ04011E

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