Issue 41, 2022

Investigating the photosensitivity of koneramines for cell imaging and therapeutic applications

Abstract

The photophysical properties of the anthracene appended koneramines (LAn) were analyzed and utilized as a chemosensor for the selective detection of Cd2+ and Zn2+. The complexation-induced inhibition of PET (photo-induced electron transfer) from the chelating nitrogen atoms to the excited state of the anthracene moiety resulted in a fluorescence “turn-on” signal upon binding with Cd2+ and Zn2+. The confocal microscopic imaging studies performed on the MCF-7 cells validated that the compound is potentially useful for detecting Cd2+ and Zn2+ inside the cells. The cadmium complex exhibited unique bactericidal activity against clinically relevant human pathogens. The excellent activity against multidrug-resistant S. aureus makes the complex useful as a new, easily synthesizable antibiotic. The cadmium complex LAnCdCl2 was not cytotoxic against vero cells with a selectivity index of 40, exhibited concentration dependent bactericidal killing, was non-interactive with several other clinically approved standard drugs, exhibited prolonged post-antibiotic effect (PAE) against S. aureus ATCC 29213 and possesses antibiofilm activity.

Graphical abstract: Investigating the photosensitivity of koneramines for cell imaging and therapeutic applications

Supplementary files

Article information

Article type
Paper
Submitted
30 авг 2022
Accepted
26 сеп 2022
First published
27 сеп 2022

Dalton Trans., 2022,51, 15659-15668

Investigating the photosensitivity of koneramines for cell imaging and therapeutic applications

S. Ghosh, A. Akhir, D. Saxena, S. Singh, S. Sivakumar, S. Chopra and R. Angamuthu, Dalton Trans., 2022, 51, 15659 DOI: 10.1039/D2DT02834D

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