Issue 17, 2022

Recent progress in antisolvent crystallization

Abstract

Antisolvent crystallization is a significant unit operation in the pharmaceutical industry, especially in drug crystal property optimization. This paper firstly highlights the applications of antisolvent crystallization in crystal engineering. Antisolvent crystallization can effectively control the product properties, such as polymorphism, morphology, and particle size optimization, to improve drug therapeutic effect. This paper also includes the process intensification pathways of antisolvent crystallization in the pharmaceutical field. Process parameter optimization and device and structure modification are considered as feasible approaches. Then, coupled techniques with antisolvent crystallization, including ultrasound and membrane intensification, are also summarized. Finally, the models and applications of continuous antisolvent crystallization are introduced to better design and optimize the processes. Also, critical concerns and opportunities for further research and perspectives are discussed.

Graphical abstract: Recent progress in antisolvent crystallization

Article information

Article type
Highlight
Submitted
12 яну 2022
Accepted
01 мар 2022
First published
22 мар 2022

CrystEngComm, 2022,24, 3122-3135

Recent progress in antisolvent crystallization

S. Jia, P. Yang, Z. Gao, Z. Li, C. Fang and J. Gong, CrystEngComm, 2022, 24, 3122 DOI: 10.1039/D2CE00059H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements