Issue 20, 2021

Inertial microfluidics for high-throughput cell analysis and detection: a review

Abstract

Since it was first proposed in 2007, inertial microfluidics has been extensively studied in terms of theory, design, fabrication, and application. In recent years, with the rapid development of microfabrication technologies, a variety of channel structures that can focus, concentrate, separate, and capture bioparticles or fluids have been designed and manufactured to extend the range of potential biomedical applications of inertial microfluidics. Due to the advantages of high throughput, simplicity, and low device cost, inertial microfluidics is a promising candidate for rapid sample processing, especially for large-volume samples with low-abundance targets. As an approach to cellular sample pretreatment, inertial microfluidics has been widely employed to ensure downstream cell analysis and detection. In this review, a comprehensive summary of the application of inertial microfluidics for high-throughput cell analysis and detection is presented. According to application areas, the recent advances can be sorted into label-free cell mechanical phenotyping, sheathless flow cytometric counting, electrical impedance cytometer, high-throughput cellular image analysis, and other methods. Finally, the challenges and prospects of inertial microfluidics for cell analysis and detection are summarized.

Graphical abstract: Inertial microfluidics for high-throughput cell analysis and detection: a review

Article information

Article type
Critical Review
Submitted
03 юни 2021
Accepted
27 авг 2021
First published
30 авг 2021

Analyst, 2021,146, 6064-6083

Inertial microfluidics for high-throughput cell analysis and detection: a review

Z. Zhou, Y. Chen, S. Zhu, L. Liu, Z. Ni and N. Xiang, Analyst, 2021, 146, 6064 DOI: 10.1039/D1AN00983D

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