Manganese-catalyzed direct C–C coupling of α-C–H bonds of amides and esters with alcohols via hydrogen autotransfer

Abstract

Herein we report an efficient manganese-catalyzed C-alkylation of unactivated amides and tert-butyl acetate using alcohols as alkylating agents. This elegant approach exhibits a broad substrate scope providing the C–C coupled products of amides via a hydrogen auto-transfer strategy using aryl, heteroaryl, and aliphatic alcohols.