Issue 88, 2019
From the journal:

Chemical Communications

Sensing of citrulline modifications in histone peptides by deep cavitand hosts†

Adam D. Gill,a   Briana L. Hickey,b   Siwen Wang,c   Min Xue,bc   Wenwan Zhong ORCID logo bc  and  Richard J. Hooley ORCID logo *ba  

* Corresponding authors

a Department of Biochemistry and Molecular Biology, University of California-Riverside, Riverside, CA 92521, USA
E-mail: richard.hooley@ucr.edu

b Department of Chemistry, University of California-Riverside, Riverside, CA 92521, USA

c Environmental Toxicology Program, University of California-Riverside, Riverside, CA 92521, USA

Abstract

Arrayed cavitand:fluorophore sensor complexes can selectively sense small citrulline modifications at arginine residues on post-translationally modified peptides. The sensor can differentiate between different numbers of citrulline modifications, and a simple two-fluorophore, 6-component array can effect cross-reactive discrimination between single modifications in aqueous solution.

Graphical abstract: Sensing of citrulline modifications in histone peptides by deep cavitand hosts

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Article information

DOI
https://doi.org/10.1039/C9CC07002H
Article type
Communication
Submitted
07 сеп 2019
Accepted
11 окт 2019
First published
11 окт 2019

Chem. Commun., 2019,55, 13259-13262

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Sensing of citrulline modifications in histone peptides by deep cavitand hosts

A. D. Gill, B. L. Hickey, S. Wang, M. Xue, W. Zhong and R. J. Hooley, Chem. Commun., 2019, 55, 13259 DOI: 10.1039/C9CC07002H

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