Issue 12, 2017

An expedient and novel strategy for reductive amination by employing H2O as both a hydrogen source and solvent via B2(OH)4/H2O systems

Abstract

An efficient, convenient and mild Ru-catalyzed reductive amination reaction was developed by employing H2O as both hydrogen source and solvent via B2(OH)4/H2O systems. The reaction proceeded smoothly under air at ambient temperature and exhibited excellent chemoselectivities toward unsaturated and heteroaromatic as well as aliphatic aldehydes. Interestingly, α-deuterated amines were also obtained expediently by employing D2O in our catalytic systems.

Graphical abstract: An expedient and novel strategy for reductive amination by employing H2O as both a hydrogen source and solvent via B2(OH)4/H2O systems

Supplementary files

Article information

Article type
Research Article
Submitted
29 авг 2017
Accepted
27 сеп 2017
First published
29 сеп 2017

Org. Chem. Front., 2017,4, 2291-2295

An expedient and novel strategy for reductive amination by employing H2O as both a hydrogen source and solvent via B2(OH)4/H2O systems

Y. Wei, C. Zhao, Q. Xuan and Q. Song, Org. Chem. Front., 2017, 4, 2291 DOI: 10.1039/C7QO00769H

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