Issue 20, 2017

One-pot Suzuki–Heck relay to prepare industrially valuable intermediates using the Pd–Cy*Phine catalyst system

Abstract

A rare example of a one-pot, palladium-catalyzed Suzuki–Heck sequence has been developed with applicability to APIs and organoelectronic materials. High throughput screening was used to expedite development and survey strategies. Interchangeability of the coupling partners and the avoidance of intermediate isolation gives operational flexibility, which can be used to improve process efficiency and suppress by-product formation.

Graphical abstract: One-pot Suzuki–Heck relay to prepare industrially valuable intermediates using the Pd–Cy*Phine catalyst system

Supplementary files

Article information

Article type
Communication
Submitted
17 юли 2017
Accepted
23 авг 2017
First published
30 авг 2017

Catal. Sci. Technol., 2017,7, 4599-4603

One-pot Suzuki–Heck relay to prepare industrially valuable intermediates using the Pd–Cy*Phine catalyst system

U. K. Das, R. Clément, C. W. Johannes, E. G. Robins, H. Jong and R. T. Baker, Catal. Sci. Technol., 2017, 7, 4599 DOI: 10.1039/C7CY01344B

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