Issue 26, 2009

Rhodium catalyzed enantioselective cyclization of substituted imidazolesvia C–H bond activation

Abstract

The enantioselective intramolecular alkylation of substituted imidazoles with enantiomeric excesses up to 98% has been accomplished by rhodium catalyzed C–H bond functionalization with (S,S′,R,R′)TangPhos as the chiral ligand.

Graphical abstract: Rhodium catalyzed enantioselective cyclization of substituted imidazoles via C–H bond activation

Supplementary files

Article information

Article type
Communication
Submitted
11 фев 2009
Accepted
01 май 2009
First published
02 юни 2009

Chem. Commun., 2009, 3910-3912

Rhodium catalyzed enantioselective cyclization of substituted imidazoles via C–H bond activation

A. S. Tsai, R. M. Wilson, H. Harada, R. G. Bergman and J. A. Ellman, Chem. Commun., 2009, 3910 DOI: 10.1039/B902878A

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