Issue 9, 2024

Photoinduced electron transfer endows fluorogenicity in tetrazine-based near-infrared labels

Abstract

Tetrazine-functionalized fluorogenic labels are pivotal in various scientific domains, but their fluorogenicity often diminishes when the emission wavelength extends into the near-infrared (NIR) region. This investigation confirms that photoinduced electron transfer (PET) is the primary mechanism causing fluorescence quenching in such NIR labels. Furthermore, we have discovered an unprecedented photoinduced charge centralization (PCC) within the conjugated frameworks of tetrazine-integrated fluorogenic dyes. These insights into the mechanisms of fluorescence quenching pave the way for advancing tetrazine chemistry at the photophysical level. Subsequently, we introduce a rational molecular design approach for crafting tetrazine-based NIR labels that leverages the PET mechanism to significantly boost their fluorogenic response.

Graphical abstract: Photoinduced electron transfer endows fluorogenicity in tetrazine-based near-infrared labels

Supplementary files

Article information

Article type
Research Article
Submitted
15 ное 2023
Accepted
06 фев 2024
First published
08 фев 2024

Mater. Chem. Front., 2024,8, 2135-2141

Photoinduced electron transfer endows fluorogenicity in tetrazine-based near-infrared labels

T. Shen, X. Li and X. Liu, Mater. Chem. Front., 2024, 8, 2135 DOI: 10.1039/D3QM01217D

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