Issue 19, 2024

Advances in carrier-delivered small interfering RNA based therapeutics for treatment of neurodegenerative diseases

Abstract

Neurodegenerative diseases are devastating diseases that severely affect the health of people all over the world. RNA therapies have become one of the most promising critical drug treatments for neurodegenerative diseases due to their excellent gene and protein editing effects. However, the successful transport of RNA via the systemic route to the central nervous system remains one of the major obstacles in treating neurodegenerative diseases. This review will focus on therapeutic RNA that can successfully overcome the blood–brain barrier (BBB), with particular attention to small interfering RNAs (siRNAs), focusing on different types of neurodegenerative disease treatment strategies and accelerating their translation into clinical practice.

Graphical abstract: Advances in carrier-delivered small interfering RNA based therapeutics for treatment of neurodegenerative diseases

Article information

Article type
Review Article
Submitted
03 юли 2024
Accepted
10 авг 2024
First published
15 авг 2024

Biomater. Sci., 2024,12, 4927-4945

Advances in carrier-delivered small interfering RNA based therapeutics for treatment of neurodegenerative diseases

W. Liang, Y. Luo, A. Xu, J. Chu, W. Ji, L. Wang, Y. Gu, X. Lu, A. Hou, Y. Liu, J. Gao and Y. Yin, Biomater. Sci., 2024, 12, 4927 DOI: 10.1039/D4BM00878B

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