Issue 12, 2023

Microfluidic synthesis of nanomaterials for biomedical applications

Abstract

The field of nanomaterials has progressed dramatically over the past decades with important contributions to the biomedical area. The physicochemical properties of nanomaterials, such as the size and structure, can be controlled through manipulation of mass and heat transfer conditions during synthesis. In particular, microfluidic systems with rapid mixing and precise fluid control are ideal platforms for creating appropriate synthesis conditions. One notable example of microfluidics-based synthesis is the development of lipid nanoparticle (LNP)-based mRNA vaccines with accelerated clinical translation and robust efficacy during the COVID-19 pandemic. In addition to LNPs, microfluidic systems have been adopted for the controlled synthesis of a broad range of nanomaterials. In this review, we introduce the fundamental principles of microfluidic technologies including flow field- and multiple field-based methods for fabricating nanoparticles, and discuss their applications in the biomedical field. We conclude this review by outlining several major challenges and future directions in the implementation of microfluidic synthesis of nanomaterials.

Graphical abstract: Microfluidic synthesis of nanomaterials for biomedical applications

Article information

Article type
Review Article
Submitted
01 юни 2023
Accepted
05 сеп 2023
First published
05 сеп 2023

Nanoscale Horiz., 2023,8, 1610-1627

Microfluidic synthesis of nanomaterials for biomedical applications

Y. Huang, C. Liu, Q. Feng and J. Sun, Nanoscale Horiz., 2023, 8, 1610 DOI: 10.1039/D3NH00217A

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